| Presence and stability of gastrin in the gastric juice of the fetal sheep. | |
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MedLine Citation:
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PMID: 6713736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although gastrin is found in adult gastric juice, rapid enzymatic destruction by pepsin in the acid environment makes a physiological role in the adult unlikely. Gastric pH in the fetal sheep is neutral so that gastric juice gastrin could be present, and if present, have a physiological function. The aim of this study was to determine the presence, molecular forms and metabolism of gastrin in gastric juice. Gastrin was present in fetal gastric juice at significantly higher concentrations than in fetal plasma. The majority of gastric juice gastrin was present as the biologically active gastrin-17. Gastrin was stable in normal fetal gastric juice, but was rapidly metabolized to smaller C-terminal fragments when the gastric juice was acidified. With the known growth promoting effect of gastrin on gastrointestinal mucosa, gastrin in fetal juice could have a unique role in the in utero development of the gastrointestinal tract. |
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Authors:
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A Shulkes; P Chick; K J Hardy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 11 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1984 Jan-Feb |
Date Detail:
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Created Date: 1984-06-19 Completed Date: 1984-06-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 45-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Gel Female Fetus / analysis Gastric Juice / analysis* Gastrins / analysis* Gestational Age Pregnancy Radioimmunoassay Sheep Stomach / embryology |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 60748-06-3/gastrin 17 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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