Document Detail


Presence and stability of gastrin in the gastric juice of the fetal sheep.
MedLine Citation:
PMID:  6713736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although gastrin is found in adult gastric juice, rapid enzymatic destruction by pepsin in the acid environment makes a physiological role in the adult unlikely. Gastric pH in the fetal sheep is neutral so that gastric juice gastrin could be present, and if present, have a physiological function. The aim of this study was to determine the presence, molecular forms and metabolism of gastrin in gastric juice. Gastrin was present in fetal gastric juice at significantly higher concentrations than in fetal plasma. The majority of gastric juice gastrin was present as the biologically active gastrin-17. Gastrin was stable in normal fetal gastric juice, but was rapidly metabolized to smaller C-terminal fragments when the gastric juice was acidified. With the known growth promoting effect of gastrin on gastrointestinal mucosa, gastrin in fetal juice could have a unique role in the in utero development of the gastrointestinal tract.
Authors:
A Shulkes; P Chick; K J Hardy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  11     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-06-19     Completed Date:  1984-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  45-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Gel
Female
Fetus / analysis
Gastric Juice / analysis*
Gastrins / analysis*
Gestational Age
Pregnancy
Radioimmunoassay
Sheep
Stomach / embryology
Chemical
Reg. No./Substance:
0/Gastrins; 60748-06-3/gastrin 17

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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