| Presence of somatostatin-28 like immunoreactivity in the human pancreas. | |
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MedLine Citation:
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PMID: 6124858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Specific antisera against somatostatin-28 were prepared by absorption of somatostatin-28 antisera with sepharose 4B-somatostatin-14. Indirect immunofluorescence techniques using somatostatin-14 antisera and specific antisera against somatostatin-28 were carried out to elucidate the time of occurrence of somatostatin-28 in the fetal pancreatic islets and to ascertain whether somatostatin-28 was present in the adult pancreatic islets or not, and further to examine whether cells reacting with specific antisera against somatostatin-28 are identical to those reacting with somatostatin-14 antisera or not. Somatostatin-28 like immunoreactivity occurred in the fetal pancreatic islets at 11th week's gestation and was found in all fetal pancreatic islets examined in the present study. It was also found in the adult pancreatic islets. Furthermore, cells reacting with specific antisera against somatostatin-28 in the fetal and adult pancreatic islets were identical to those reacting with somatostatin-14 antisera. Thus, the present study elucidated the presence of somatostatin-28 like immunoreactivity in the human pancreas. However, it could not be decided whether cells reacting with somatostatin-28 antisera contain either only somatostatin-28 or both somatostatin-28 and somatostatin-14; in other words, whether somatostatin-14 is produced from somatostatin-28 or not, since somatostatin-14 antisera had a cross-reactivity to both somatostatin-14 and somatostatin-28. |
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Authors:
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S Ito; Y Yamada; T Iwanaga; A Shibata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 30 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1982 May |
Date Detail:
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Created Date: 1982-09-17 Completed Date: 1982-09-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1707-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross Reactions Fluorescent Antibody Technique Humans Immune Sera / immunology Islets of Langerhans / analysis*, embryology Somatostatin / analysis*, immunology Somatostatin-28 |
| Chemical | |
Reg. No./Substance:
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0/Immune Sera; 51110-01-1/Somatostatin; 75037-27-3/Somatostatin-28 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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