Document Detail

Presence of somatostatin-28 like immunoreactivity in the human pancreas.
MedLine Citation:
PMID:  6124858     Owner:  NLM     Status:  MEDLINE    
Specific antisera against somatostatin-28 were prepared by absorption of somatostatin-28 antisera with sepharose 4B-somatostatin-14. Indirect immunofluorescence techniques using somatostatin-14 antisera and specific antisera against somatostatin-28 were carried out to elucidate the time of occurrence of somatostatin-28 in the fetal pancreatic islets and to ascertain whether somatostatin-28 was present in the adult pancreatic islets or not, and further to examine whether cells reacting with specific antisera against somatostatin-28 are identical to those reacting with somatostatin-14 antisera or not. Somatostatin-28 like immunoreactivity occurred in the fetal pancreatic islets at 11th week's gestation and was found in all fetal pancreatic islets examined in the present study. It was also found in the adult pancreatic islets. Furthermore, cells reacting with specific antisera against somatostatin-28 in the fetal and adult pancreatic islets were identical to those reacting with somatostatin-14 antisera. Thus, the present study elucidated the presence of somatostatin-28 like immunoreactivity in the human pancreas. However, it could not be decided whether cells reacting with somatostatin-28 antisera contain either only somatostatin-28 or both somatostatin-28 and somatostatin-14; in other words, whether somatostatin-14 is produced from somatostatin-28 or not, since somatostatin-14 antisera had a cross-reactivity to both somatostatin-14 and somatostatin-28.
S Ito; Y Yamada; T Iwanaga; A Shibata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  30     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1707-11     Citation Subset:  IM    
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MeSH Terms
Cross Reactions
Fluorescent Antibody Technique
Immune Sera / immunology
Islets of Langerhans / analysis*,  embryology
Somatostatin / analysis*,  immunology
Reg. No./Substance:
0/Immune Sera; 51110-01-1/Somatostatin; 75037-27-3/Somatostatin-28

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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