Document Detail

Presence and severity of Chlamydia pneumoniae and Cytomegalovirus infection in coronary plaques are associated with acute coronary syndromes.
MedLine Citation:
PMID:  16960406     Owner:  NLM     Status:  MEDLINE    
Although an association between Chlamydia pneumoniae (Cpn) or Cytomegalovirus (CMV) infection and coronary atherosclerosis has been reported, such an association is less clear for acute coronary syndromes (ACS). The purpose of this study was to investigate the pathogenic roles of Cpn and CMV infection of coronary plaques in ACS. We divided 38 coronary plaque specimens obtained from 38 patients who underwent directional coronary atherectomy or thrombectomy into an ACS group (n = 21) and a non-ACS group (n = 17). Cpn and CMV in specimens were stained using immunohistochemical techniques and analyzed quantitatively. The detection rate for either Cpn- or CMV-positive cells in ACS patients was slightly higher compared with non-ACS patients. Detection rates for both Cpn- and CMV-positive cells were significantly higher in ACS patients than in non-ACS patients (P = 0.010). Furthermore, the density of Cpn- and CMV-positive cells in plaques was significantly higher in ACS patients than in non-ACS patients (P < 0.003). The results indicate that the presence and severity of Cpn and CMV infection in coronary plaques are greater in patients with ACS compared with non-ACS patients. We conclude that infection with Cpn and CMV in coronary plaques may be involved in the pathogenesis of ACS.
Ruiqin Liu; Masao Moroi; Masato Yamamoto; Tetsuya Kubota; Tsuyoshi Ono; Atsushi Funatsu; Hiroki Komatsu; Takahiro Tsuji; Hisao Hara; Hidehiko Hara; Masato Nakamura; Hironori Hirai; Tetsu Yamaguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International heart journal     Volume:  47     ISSN:  1349-2365     ISO Abbreviation:  -     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2007-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  511-9     Citation Subset:  IM    
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Ohashi, Meguro-ku, Tokyo, Japan.
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MeSH Terms
Antibodies, Bacterial / analysis
Antibodies, Viral / analysis
Atherectomy, Coronary / methods
Chlamydophila Infections / complications*,  diagnosis,  microbiology
Chlamydophila pneumoniae / immunology*
Coronary Angiography
Coronary Artery Disease / complications*,  microbiology,  surgery,  virology
Coronary Thrombosis / diagnosis,  etiology*,  surgery
Cytomegalovirus / immunology*
Cytomegalovirus Infections / complications*,  diagnosis,  virology
Follow-Up Studies
Middle Aged
Retrospective Studies
Rupture, Spontaneous
Thrombectomy / methods
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antibodies, Viral

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