Document Detail


Presence and progression of abdominal obesity are predictors of future high blood pressure and hypertension.
MedLine Citation:
PMID:  16876676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: General obesity and its progression are major predictors of future hypertension. It has not been established whether abdominal obesity contributes to the development of hypertension. METHODS: A community-based study population of 2377 normotensive nondiabetic Chinese adults aged >or=30 years were re-examined 10 years after their baseline examination. RESULTS: The 10-year cumulative incidence of hypertension was 25.9%. The standardized parameters for the prediction of follow-up systolic blood pressure (BP) for baseline body mass index (BMI), change in BMI, baseline homeostasis model assessment of insulin resistance (HOMA-IR), change in HOMA-IR, baseline waist circumference (WC), and change in WC were 0.19 (P < .001), 0.09 (P < .001), 0.11 (P < .001), 0.08 (P < .001), 0.16 (P < .001), and 0.07 (P < .001), respectively, when age, sex, and baseline systolic BP were accounted for. By stepwise linear regression analysis, age, baseline systolic BP, baseline BMI, change in BMI, baseline WC, and change in WC were significant predictors of the follow-up systolic BP. Both baseline WC and change in WC were significant predictors of follow-up systolic BP or incident hypertension when age, sex, baseline systolic BP, BMI, and change in BMI were accounted for. In a subgroup of younger adults with normal BMI and BP<130/85 mm Hg, baseline systolic BP, change in HOMA-IR, baseline WC, and change in WC were significantly independent predictors of follow-up systolic BP. CONCLUSION: Abdominal obesity and its progression are predictors of future BP and hypertension incidence, independent of the effects of general obesity.
Authors:
Shao-Yuan Chuang; Pesus Chou; Pai-Feng Hsu; Hao-Min Cheng; Shih-Tzer Tsai; I-Feng Lin; Chen-Huan Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  19     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-12-04     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  788-95     Citation Subset:  IM    
Affiliation:
Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat / pathology*
Adult
Blood Pressure*
Body Mass Index
Disease Progression
Female
Follow-Up Studies
Humans
Hypertension / complications*,  diagnosis,  epidemiology,  physiopathology
Insulin Resistance
Male
Middle Aged
Obesity / complications*,  epidemiology,  pathology,  physiopathology
Prognosis

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