Document Detail

Presence of nonesterified and acylcarnitine in human polymorphonuclear leukocytes and mononuclear cells.
MedLine Citation:
PMID:  3829385     Owner:  NLM     Status:  MEDLINE    
We demonstrate the presence of nonesterified carnitine and acylcarnitine in leukocytes, but not in erythrocytes, from 16 healthy adults. After carefully separating the different kinds of blood cells we measured significant amounts of nonesterified carnitine and acylcarnitine in polymorphonuclear leukocytes (28.5 +/- 6.1 and 18.5 +/- 6.3 mumol/10(9) cells) and mononuclear cells (25.4 +/- 5.2 and 14.8 +/- 4.5 mumol/10(9) cells). We also measured nonesterified carnitine, long-chain acylcarnitine, and short-chain acylcarnitine in plasma after fractionation with perchloric acid and obtained the following values (mean +/- SD): 41.4 +/- 2.6, 3.9 +/- 1.2, and 6.0 +/- 1.6 mumol/L, respectively. The mean percentages of total carnitine (n = 6) in polymorphonuclear leukocytes, mononuclear cells, and plasma were approximately 62%, 27%, and 13% of whole-blood carnitine, respectively (mean recovery was 102%). The percentage of acylated carnitine was 37% in leukocytes, as compared with 19% in plasma.
K Katrib; H A Adlouni; G Férard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  33     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-05-18     Completed Date:  1987-05-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  533-5     Citation Subset:  IM    
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MeSH Terms
Carnitine / blood*
Energy Metabolism
Esters / blood
Monocytes / analysis*
Neutrophils / analysis*
Reg. No./Substance:
0/Esters; 541-15-1/Carnitine

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