| Presence of mucosal change in the urinary bladder in nonhematuric patients with long-term exposure and/or accumulating high-dose cyclophosphamide. Possible significance of follow-up cystoscopy on preventing development of cyclophosphamide-induced hemorrhagic cystitis. | |
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MedLine Citation:
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PMID: 9792975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Cyclophosphamide (CPA)-induced hemorrhagic cystitis is sometimes difficult to manage. We investigated the mucosal changes in patients subjected to CPA therapy in relation to the duration and accumulating dose of CPA. METHODS: Fifteen patients, all of whom were receiving CPA, were studied. Investigation of the dose and duration of CPA administration, urinalysis and cystoscopy was performed. RESULTS: The total doses of CPA administered ranged from 2.5 to 237.0 g, and the duration of administration ranged from 4 to 130 months. Four patients with hematuria (micro or macro) showed various degrees of mucosal hyperemia and telangiectasia. Of 11 patients without microhematuria, 6 patients also revealed mucosal changes distinctive of CPA-induced hemorrhagic cystitis. CPA-induced cystitis with no hematuria insidiously progressed in the patients who received CPA orally at a total dose of more than 40 g and/or for longer than 36 months. CONCLUSION: Early mucosal lesion of the urinary bladder, which will most likely be followed by CPA-induced hemorrhagic cystitis, may develop prior to the appearance of microscopic hematuria. Periodic prophylactic cystoscopy is recommend in patients receiving CPA. |
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Authors:
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M Kimura; Y Tomita; H Morishita; K Takahashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Urologia internationalis Volume: 61 ISSN: 0042-1138 ISO Abbreviation: Urol. Int. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-01-06 Completed Date: 1999-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417373 Medline TA: Urol Int Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 8-11 Citation Subset: IM |
Affiliation:
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Department of Urology, Nagaoka Red Cross Hospital, Niigata, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cyclophosphamide / administration & dosage, adverse effects* Cystitis / chemically induced*, prevention & control Cystoscopy Female Hematuria / chemically induced*, prevention & control Humans Male Middle Aged Mucous Membrane / pathology Urinary Bladder / pathology* |
| Chemical | |
Reg. No./Substance:
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50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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