Document Detail

Presence of kynurenic acid in food and honeybee products.
MedLine Citation:
PMID:  18231708     Owner:  NLM     Status:  MEDLINE    
Kynurenic acid (KYNA) is an endogenous antagonist of ionotropic glutamate receptors and the alpha 7 nicotinic acetylcholine receptor, showing anticonvulsant and neuroprotective activity. In this study, the presence of KYNA in food and honeybee products was investigated. KYNA was found in all 37 tested samples of food and honeybee products. The highest concentration of KYNA was obtained from honeybee products' samples, propolis (9.6 nmol/g), honey (1.0-4.8 nmol/g) and bee pollen (3.4 nmol/g). A high concentration was detected in fresh broccoli (2.2 nmol/g) and potato (0.7 nmol/g). Only traces of KYNA were found in some commercial baby products. KYNA administered intragastrically in rats was absorbed from the intestine into the blood stream and transported to the liver and to the kidney. In conclusion, we provide evidence that KYNA is a constituent of food and that it can be easily absorbed from the digestive system.
Michal P Turski; Monika Turska; Wojciech Zgrajka; Damian Kuc; Waldemar A Turski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-30
Journal Detail:
Title:  Amino acids     Volume:  36     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  75-80     Citation Subset:  IM    
Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950, Lublin, Poland.
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MeSH Terms
Bees / chemistry*
Food Analysis*
Kynurenic Acid / analysis*,  pharmacokinetics
Organ Specificity / drug effects
Rats, Wistar
Reg. No./Substance:
492-27-3/Kynurenic Acid

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