| Presence of immunoreactive endothelin-1 and atrial natriuretic peptide in human pericardial fluid. | |
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MedLine Citation:
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PMID: 9488105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to characterize endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) concentrations in human pericardial fluid, blood plasma, right atrial appendage and papillary muscle by use of specific radioimmunoassays. In patients undergoing cardiac surgery (n=16) pericardial fluid mean immunoreactive (ir-) ET-1 and ir-ANP levels were 36-fold and 4-fold higher than corresponding plasma levels, respectively. In high performance liquid chromatography (HPLC) pericardial fluid ir-ET-1 was indistinguishable from human ET-1[1-21] and the majority of pericardial fluid ir-ANP coeluted with human ANP[99-126]. Atrial tissue ir-ET-1 and ir-ANP concentrations were 17-fold and 870-fold higher than in ventricular tissue. Our present study demonstrated for the first time the presence of ir-ET-1 in the pericardial fluid in humans. Human pericardial fluid contained far the highest concentrations of ET-1 among all biological fluids tested thus far. The functions of pericardial fluid ET-1 and ANP on cardiac performance and coronary vascular tone require further investigations. |
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Authors:
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F Horkay; I Szokodi; L Selmeci; B Merkely; V Kékesi; T Vecsey; O Vuolteenaho; H Ruskoaho; A Juhász-Nagy; M Tóth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 62 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-03-12 Completed Date: 1998-03-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 267-74 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Semmelweis University of Medicine, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrial Natriuretic Factor / blood, metabolism* Body Fluids / enzymology, metabolism* Chromatography, High Pressure Liquid Endothelin-1 / blood, metabolism* Female Heart Atria / metabolism Humans Male Middle Aged Neprilysin / metabolism Pericardium / enzymology, metabolism* Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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