Document Detail

Presence of human papillomavirus in genital tumors.
MedLine Citation:
PMID:  6330218     Owner:  NLM     Status:  MEDLINE    
Human papillomavirus (HPV) types 16 and 18 have been identified in two different human cervical carcinomas. The viral DNAs were molecularly cloned and used as probes to screen a large number of genital tumors by Southern blot analysis. HPV-16 or HPV-18 sequences, respectively, were found in a high percentage of cervical carcinomas, but only in a small number of condylomata acuminata or flat condylomas. The majority of the latter lesions, however, contained HPV-6 or HPV-11 sequences, respectively, which in contrast were detected only rarely in carcinomas in situ or invasively growing carcinomas. A similar distribution of the different papillomaviruses was observed when cell swabs taken from the cervix were tested by in situ hybridization.
L Gissmann; M Boshart; M Dürst; H Ikenberg; D Wagner; H zur Hausen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  83     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-13     Completed Date:  1984-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26s-28s     Citation Subset:  IM    
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MeSH Terms
Cloning, Molecular
Condylomata Acuminata / microbiology*
DNA, Viral / genetics
Nucleic Acid Hybridization
Papillomaviridae / genetics,  isolation & purification*
Tumor Virus Infections / microbiology*
Uterine Cervical Neoplasms / microbiology*
Vaginal Smears
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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