| Presence of human beta- and gamma-herpes virus DNA in Hodgkin's disease. | |
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MedLine Citation:
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PMID: 10996205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herpes viruses have been implicated in the etiology of Hodgkin's disease (HD). We studied the prevalence of human cytomegalovirus (CMV), human herpes viruses type-6 (HHV-6), type-7 (HHV-7) and type 8 (HHV-8) DNA in up to 88 Hodgkin's disease biopsies in comparison to Epstein-Barr virus (EBV) DNA by polymerase chain reaction (PCR). Non-Hodgkin lymphomas (NHL) and reactive lesions served as controls. CMV and HHV-6 were found in 8/86 (9%) and 11/88 (13%) HD cases, respectively, by nested primer PCR. Except for three cases harbouring HHV-6 type-B, only HHV-6 type-A was detected in HD. HHV-7 was observed by nested PCR in 33/88 (38%) HD cases and was already detectable in 15/88 (17%) HD cases by a single-round PCR indicating elevated virus copy numbers. Seven of these cases showed co-infection with HHV-6, and 11 cases were found to contain EBV DNA. 7/8 CMV-positive HD cases also harboured EBV DNA. HHV-8 DNA was not detected by single round or nested PCR in any HD case investigated. Thus, CMV, HHV-6, and HHV-7 were present in small proportions of HD cases, with frequent co-infection of HHV-6 and HHV-7, and frequent association with EBV. In contrast to EBV, beta-herpes viruses are therefore unlikely to have a role in the aetiology of HD. Rather, the presence of these viruses seems to reflect impaired immunological surveillance. |
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Authors:
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C A Schmidt; H Oettle; R Peng; T Binder; F Wilborn; D Huhn; W Siegert; H Herbst |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Leukemia research Volume: 24 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-10-26 Completed Date: 2000-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 865-70 Citation Subset: IM |
Affiliation:
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Abteilung für Innere Medizin, Hämatologie und Onkologie, Virchow-Klinikum, Humboldt-Universität, Berlin, Germany. christian.schmidt@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Betaherpesvirinae
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genetics,
isolation & purification* Cytomegalovirus / genetics DNA, Viral / analysis* Gammaherpesvirinae / genetics, isolation & purification* Herpesvirus 4, Human / genetics Herpesvirus 6, Human / genetics Herpesvirus 7, Human / genetics Herpesvirus 8, Human / genetics Hodgkin Disease / virology* Humans |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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