Document Detail

Presence of human beta- and gamma-herpes virus DNA in Hodgkin's disease.
MedLine Citation:
PMID:  10996205     Owner:  NLM     Status:  MEDLINE    
Herpes viruses have been implicated in the etiology of Hodgkin's disease (HD). We studied the prevalence of human cytomegalovirus (CMV), human herpes viruses type-6 (HHV-6), type-7 (HHV-7) and type 8 (HHV-8) DNA in up to 88 Hodgkin's disease biopsies in comparison to Epstein-Barr virus (EBV) DNA by polymerase chain reaction (PCR). Non-Hodgkin lymphomas (NHL) and reactive lesions served as controls. CMV and HHV-6 were found in 8/86 (9%) and 11/88 (13%) HD cases, respectively, by nested primer PCR. Except for three cases harbouring HHV-6 type-B, only HHV-6 type-A was detected in HD. HHV-7 was observed by nested PCR in 33/88 (38%) HD cases and was already detectable in 15/88 (17%) HD cases by a single-round PCR indicating elevated virus copy numbers. Seven of these cases showed co-infection with HHV-6, and 11 cases were found to contain EBV DNA. 7/8 CMV-positive HD cases also harboured EBV DNA. HHV-8 DNA was not detected by single round or nested PCR in any HD case investigated. Thus, CMV, HHV-6, and HHV-7 were present in small proportions of HD cases, with frequent co-infection of HHV-6 and HHV-7, and frequent association with EBV. In contrast to EBV, beta-herpes viruses are therefore unlikely to have a role in the aetiology of HD. Rather, the presence of these viruses seems to reflect impaired immunological surveillance.
C A Schmidt; H Oettle; R Peng; T Binder; F Wilborn; D Huhn; W Siegert; H Herbst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia research     Volume:  24     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-26     Completed Date:  2000-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  865-70     Citation Subset:  IM    
Abteilung für Innere Medizin, Hämatologie und Onkologie, Virchow-Klinikum, Humboldt-Universität, Berlin, Germany.
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MeSH Terms
Betaherpesvirinae / genetics,  isolation & purification*
Cytomegalovirus / genetics
DNA, Viral / analysis*
Gammaherpesvirinae / genetics,  isolation & purification*
Herpesvirus 4, Human / genetics
Herpesvirus 6, Human / genetics
Herpesvirus 7, Human / genetics
Herpesvirus 8, Human / genetics
Hodgkin Disease / virology*
Reg. No./Substance:
0/DNA, Viral

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