Document Detail


Presence of human beta-defensin-2 in oral squamous cell carcinoma.
MedLine Citation:
PMID:  10928142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to demonstrate immunohistochemically the localization and distribution of human beta-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.
Authors:
N Mizukawa; K Sawaki; E Yamachika; J Fukunaga; T Ueno; S Takagi; T Sugahara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  20     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-08-17     Completed Date:  2000-08-17     Revised Date:  2010-09-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2005-7     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Surgery 1, Okayama University Dental School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / chemistry*
Cell Differentiation
Humans
Immunoenzyme Techniques
Mouth Neoplasms / chemistry*
Neoplasm Proteins / analysis*
Peptides / analysis*
beta-Defensins*
Chemical
Reg. No./Substance:
0/DEFB4A protein, human; 0/Neoplasm Proteins; 0/Peptides; 0/beta-Defensins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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