Document Detail

Presence of histamine H2-receptors on human gastric carcinoma cell line MKN-45 and their increase by retinoic acid treatment.
MedLine Citation:
PMID:  1674864     Owner:  NLM     Status:  MEDLINE    
Histamine dose-dependently stimulated cyclic AMP production in human gastric carcinoma cell line MKN-45, and this effect was inhibited by cimetidine but not by pyrilamine. Moreover, not only histamine but also cimetidine displaced the specific binding of [3H]tiotidine to these cells, whereas pyrilamine had no effect. On the other hand, pretreatment of MKN-45 cells with retinoic acid (RA) significantly enhanced histamine-induced increase of cyclic AMP production, although the cyclic AMP response to either forskolin or NaF was not affected. Finally, RA treatment increased the number of histamine receptor without altering its affinity. Thus, it appears that histamine H2-receptors are present on MKN-45 cells, and that RA treatment enhances the action of histamine on these cells by increasing the number of H2-receptors.
N Arima; Y Yamashita; H Nakata; A Nakamura; Y Kinoshita; T Chiba
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  176     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-07-03     Completed Date:  1991-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1027-32     Citation Subset:  IM    
Third Division, Kobe University School of Medicine, Japan.
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MeSH Terms
Binding, Competitive
Cell Line
Cimetidine / analogs & derivatives,  metabolism,  pharmacology
Cyclic AMP / metabolism
Histamine / pharmacology
Histamine H2 Antagonists / metabolism
Receptors, Histamine H2 / drug effects,  metabolism*
Stomach Neoplasms
Tretinoin / pharmacology*
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Receptors, Histamine H2; 302-79-4/Tretinoin; 51-45-6/Histamine; 51481-61-9/Cimetidine; 60-92-4/Cyclic AMP; 69014-14-8/tiotidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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