Document Detail

Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome.
MedLine Citation:
PMID:  18417367     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Metabolic syndrome is a cluster of different clinical manifestations that are risk factors for atherothrombotic cardiovascular disorders. Fatty-acid-binding protein 4 (FABP4/aP2), which is highly expressed in adipocytes, specifically exerts intracellular lipid trafficking. A high level of fatty-acid-binding protein 4 expression present in obese subjects has also been found in mice and humans, especially in macrophages at atherosclerotic lesions. An in vivo study demonstrated that the inhibitor of aP2 would be a new therapeutic agent for treating metabolic diseases in mice. We have investigated the mRNA expression of fatty-acid-binding protein 4 in human epicardial adipose and ascending aorta tissues of metabolic syndrome and nonmetabolic syndrome patients. METHODS: Paired epicardial adipose and ascending aorta tissue samples were obtained from 10 metabolic syndrome patients and 4 nonmetabolic syndrome patients during coronary bypass grafting and aortic valve replacement therapy, respectively. Fatty-acid-binding protein 4 gene expression was determined by quantitative real-time polymerase chain reaction. RESULTS AND CONCLUSIONS: Fatty-acid-binding protein 4 expression of epicardial adipose tissue was significantly higher in metabolic syndrome patients than in nonmetabolic syndrome controls (P<.05). In metabolic syndrome patients, fatty-acid-binding protein 4 expression in epicardial adipose tissue was 66 times higher than fatty-acid-binding protein 4 expression in ascending aorta tissue. The expression level of fatty-acid-binding protein 4 in epicardial adipose tissue was found to be significantly correlated with waist circumference in all subjects (r=.535, P<.05). Our data showed for the first time that human epicardial adipose and ascending aorta tissues express fatty-acid-binding protein 4 and that its level of expression in epicardial adipose tissues of metabolic syndrome patients is elevated. Increased fatty-acid-binding protein 4 gene expression in epicardial adipose tissues of metabolic syndrome patients led us think that fatty-acid-binding protein 4 might be an important factor in metabolic syndrome.
Burcak Vural; Fatmahan Atalar; Cavlan Ciftci; Ayse Demirkan; Belgin Susleyici-Duman; Demet Gunay; Belhhan Akpinar; Ertan Sagbas; Ugur Ozbek; Ahmet Sevim Buyukdevrim
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Publication Detail:
Type:  Journal Article     Date:  2008-04-15
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  17     ISSN:  1879-1336     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-8     Citation Subset:  IM    
Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Adipose Tissue / metabolism*
Aorta / metabolism
Fatty Acid-Binding Proteins / biosynthesis*
Gene Expression
Metabolic Syndrome X / metabolism*
Middle Aged
Pericardium / metabolism*
RNA, Messenger / analysis
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/FABP4 protein, human; 0/Fatty Acid-Binding Proteins; 0/RNA, Messenger

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