Document Detail

Presence of epileptiform discharges on initial EEGs are associated with failure of retention on first antiepileptic drug in newly diagnosed cryptogenic partial epilepsy: a 2-year observational study.
MedLine Citation:
PMID:  20732823     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Approximately two-thirds of the patients with newly diagnosed partial epilepsy remained on their first antiepileptic drug (AED) for 2 years in clinical practice. We aimed to analyze retention on the first AED for 2 years in newly diagnosed cryptogenic partial epilepsy patients in clinical practice and whether the presence of epileptiform discharges on the initial EEG was a predictor of the failure of retention on the first AED.
METHODS: For the purpose of this study, we retrospectively reviewed epilepsy database. On the Epilepsy Database, we found 495 newly diagnosed epilepsy patients who had been followed up for at least 2 years. Of these 495 newly diagnosed epilepsy patients, 172 patients had cryptogenic partial epilepsy. The outcome of this study was the retention rate for the first AED for 2 years. In addition, we analyzed the retention on first AED according to the presence or absence of epileptiform discharges on the initial EEG using Kaplan-Meier survival analysis.
RESULTS: Overall, retention rate on the first AED for 2 years was 51%. The main lesion of retention failure was a lack of tolerance. The presence of epileptiform discharges on the initial EEGs was significantly related to the failure of retention on the first AED (p=0.003).
CONCLUSIONS: In newly diagnosed cryptogenic partial epilepsy, overall retention on the first AED was not significantly different from that in newly diagnosed partial epilepsy. In clinical practice, epileptiform discharges on the initial EEG could predict the failure of retention on the first AED for 2 years.
Sung Eun Kim; Kang Min Park; Sang Ho Kim; Oh Young Kwon; Soon Ki No
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-21
Journal Detail:
Title:  Seizure     Volume:  19     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-01-28     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  536-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Anticonvulsants / therapeutic use*
Brain / drug effects,  physiopathology
Carbamazepine / analogs & derivatives,  therapeutic use
Electroencephalography / drug effects
Epilepsy, Complex Partial / drug therapy*,  physiopathology
Fructose / analogs & derivatives,  therapeutic use
Kaplan-Meier Estimate
Middle Aged
Phenytoin / therapeutic use
Retrospective Studies
Treatment Outcome
Triazines / therapeutic use
Valproic Acid / therapeutic use
Young Adult
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; 0/oxcarbamazepine; 0H73WJJ391/topiramate; 30237-26-4/Fructose; 33CM23913M/Carbamazepine; 614OI1Z5WI/Valproic Acid; 6158TKW0C5/Phenytoin; U3H27498KS/lamotrigine

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