Document Detail


Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1α are associated with ascending aorta aneurysm size.
MedLine Citation:
PMID:  21481600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Circulating endothelial progenitor cells (EPCs) are a specialized subset of stem/progenitor cells found in bone marrow. They participate in neo-vascularization of injured vessels and predict cardiovascular outcome in patient at risk. Several factors influence their migration and proliferation, among which is the widely studied stromal-derived factor-1α (SDF-1α). In cardiovascular disease, regarding thoracic aortic aneurysms (TAAs), few studies have investigated the levels of EPC and SDF-1α. As rupture, acute dissection and hematoma are acute complications of idiopathic ascending thoracic aortic aneurysm (iATAA) that increase with the size of aneurysm, we aimed to evaluate a potential relationship between circulating EPC and SDF-1α and iATAA size.
METHODS: The aneurysm size of 27 consecutive patients suffering from iATAA and scheduled for surgery was assessed by computed tomography scan. In all patients, we measured levels of circulating EPCs by flow cytometer, and plasma levels of SDF-1α the day before surgery. Results: The median aneurysm size was 54 mm (interquartile range (IQR): 50.0-58.8]. The EPC levels of CD34+/CD144+/CD14- and CD34+/VEGF-R2+/CD14- were inversely correlated to aneurysm diameter (p = 0.038, r = -0.424 and p = 0.0046, r = -0.65, respectively) before surgery. Conversely, plasma levels of SDF-1α were positively correlated to aneurysm size (p = 0.042; r = 0.47). Conclusions: Our findings indicate that EPC levels may be useful for monitoring ascending aorta aneurysms and that SDF-1α could be a biomarker of iATAA expansion.
Authors:
Eric Parietti; Jean-René Pallandre; Frederic Deschaseaux; Bertrand Aupècle; Camille Durst; Jean-Pierre Kantelip; Sidney Chocron; Siamak Davani
Publication Detail:
Type:  Journal Article     Date:  2011-04-09
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  40     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2012-01-13     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  e6-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Cardio-thoracic Surgery, CHU Besançon, EA 3920, IFR 133, University of Franche-Comté, Besancon, France.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, CD / blood
Aortic Aneurysm / blood*,  pathology,  radiography,  surgery
Biological Markers / blood
Blood Vessel Prosthesis Implantation / methods
Cell Movement / physiology
Chemokine CXCL12 / blood*
Endothelial Cells / immunology,  physiology*
Female
Flow Cytometry / methods
Humans
Immunophenotyping
Male
Middle Aged
Stem Cells / immunology,  physiology*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Biological Markers; 0/CXCL12 protein, human; 0/Chemokine CXCL12

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