| Presence of a central vein within white matter lesions on susceptibility weighted imaging: a specific finding for multiple sclerosis? | |
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MedLine Citation:
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PMID: 20585764 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Susceptibility weighted imaging depicts the perivenous extent of multiple sclerosis white matter lesions (MS-WML) in vivo by directly visualizing their centrally running vein. The aim of this study was to investigate the specificity of this finding for MS. METHODS: Fifteen patients with MS and 15 patients with microangiopathic white matter lesions (mWML) underwent 3T MRI, including a fluid-attenuated inversion recovery sequence (FLAIR) and a susceptibility weighted angiography (SWAN). All WMLs were identified on FLAIR and assigned to one of the following localizations: supratentorial peripheral, supratentorial periventricular, or infratentorial. Subsequently, the presence of a central vein within these lesions was assessed on SWAN. RESULTS: A total of 711 MS-WMLs and 1,119 m-WMLs were identified on FLAIR, all of which could also be visualized on SWAN. A central vein was detectable in 80% of the MS-WMLs and in 78% of the m-WMLs (in 73% and 76% of the peripheral, in 92% and 94% of the periventricular, and in 71% and 75% of the infratentorial MS-WMLs and m-WMLs, respectively). With regard to the supratentorial peripheral lesions, significantly more m-WMLs showed a central vein compared to the MS-WMLs. For the other localizations, there was no significant difference between the groups with regard to the percentage of lesions with central vein. CONCLUSIONS: Our results indicate that the detection of a central vein within a WML should not be considered a specific finding for MS; it is also found in WMLs of other etiologies. |
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Authors:
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Nina Lummel; Tobias Boeckh-Behrens; Veronika Schoepf; Michael Burke; Hartmut Brückmann; Jennifer Linn |
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Publication Detail:
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Type: Journal Article Date: 2010-06-29 |
Journal Detail:
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Title: Neuroradiology Volume: 53 ISSN: 1432-1920 ISO Abbreviation: Neuroradiology Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
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Languages: eng Pagination: 311-7 Citation Subset: IM |
Affiliation:
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Department of Neuroradiology, University of Munich, Marchioninistrasse 15, 81377, Munich, Germany, nina.lummel@med.uni-muenchen.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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