Document Detail

Presence of beta-arrestin-1 immunoreactivity in the cutaneous nerve fibers of rat glabrous skin.
MedLine Citation:
PMID:  14519533     Owner:  NLM     Status:  MEDLINE    
beta-Arrestin-1 (betaArr1) plays a major role in the desensitization and internalization of G protein-coupled receptors. We previously localized betaArr1 in the sensory neurons of rat lumbar 4 and 5 dorsal root ganglia (DRG) and reported the predominant presence of betaArr1 in the small-diameter DRG neurons that are often implicated with nociception. Because of betaArr1's crucial role in regulating the initiation of cellular signaling, in the current study we evaluated the distribution of betaArr1 in the peripheral sensory terminals where various receptors are present. Western blotting confirmed the presence of betaArr1 immunoreactivity in the rat skin. Sciatic nerve ligation demonstrated that betaArr1 is transported peripherally from the DRG, and immunohistochemistry showed betaArr1 immunoreactivity in the glabrous skin of the rat hindpaw. In the glabrous skin, strong betaArr1 immunoreactivity was detected in nerve fibers in the dermal nerve plexus and dermal papillae. Fine varicose immunoreactive fibers were found in the epidermis. In addition, betaArr1 was observed in specialized sensory receptors such as Meissner corpuscles. Our observations thus indicate that betaArr1 may be involved in modulation of specific tactile stimulation from the skin in addition to nociception.
Naoka Komori; Jane Neal; Sandra D Cain; Justin Logan; Celeste Wirsig; Kenneth E Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  988     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-01     Completed Date:  2003-12-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  121-9     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK 73190, USA.
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MeSH Terms
Arrestins / analysis*
Blotting, Western
Epidermis / chemistry*
Ganglia, Spinal / metabolism
Mechanoreceptors / chemistry
Nerve Fibers / chemistry*
Neurons, Afferent / chemistry*
Rats, Sprague-Dawley
Sciatic Nerve / injuries
Sensory Receptor Cells / chemistry
Skin / chemistry*
Reg. No./Substance:
0/Arrestins; 0/beta-arrestin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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