Document Detail

Presence of a basic amino acid residue at either position 66 or 122 is a condition for enzymic activity in the ribonuclease superfamily.
MedLine Citation:
PMID:  2673839     Owner:  NLM     Status:  MEDLINE    
Some members of the ribonuclease superfamily differ at more than 50% of the amino acid positions. Although the three-dimensional structures probably are very similar and the active-site residues have been conserved, other substrate-binding regions have changed considerably. Several proteins in the superfamily are active ribonucleases while other exhibit practically no enzymic activity. The presence of a basic residue at either position 66 or 122 appears to be a condition for ribonuclease activity.
J J Beintema
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  FEBS letters     Volume:  254     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-23     Completed Date:  1989-10-23     Revised Date:  2011-07-19    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Biochemisch Laboratorium, Groningen, The Netherlands.
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MeSH Terms
Amino Acid Sequence
Amino Acids / analysis*
Binding Sites
Molecular Sequence Data
Molecular Structure
Proteins / analysis
Ribonuclease, Pancreatic / analysis*
Ribonucleases / analysis*
Species Specificity
Reg. No./Substance:
0/Amino Acids; 0/Proteins; EC 3.1.-/Ribonucleases; EC 3.1.27.-/angiogenin; EC, Pancreatic

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