Document Detail

Presence of alpha-1-antitrypsin in pancreatic carcinoma. Report of four cases in association with hepatic storage of the protease inhibitor.
MedLine Citation:
PMID:  6205671     Owner:  NLM     Status:  MEDLINE    
Among 13 patients with accumulation of alpha-1-antitrypsin (AAT) globules in periportal hepatocytes, 4 were found to have a pancreatic malignant tumor. Three tumors presented features of well-differentiated adenocarcinoma, the fourth was a poorly differentiated carcinoma displaying a glandular differentiation in its lymph node metastases. AAT immunoreactivity was detected in tumor cells from all 4 cases in either the primary or metastatic site. Two tumors contained Grimelius-positive cells; most of them were also positive for AAT. In addition, AAT immunoreactivity was observed in cells from normal large excretory ducts of the pancreas. AAT-positive tumor cells were negative on staining for other normal plasma (e.g. albumin and fibrinogen) or tissue-associated proteins (e.g. alpha-fetoprotein and human chorionic gonadotrophin). The findings appear to suggest: the pancreas adenocarcinoma as an additional malignant tumor with AAT positivity; a possible malignant proliferation of AAT containing cells in the pancreas ducts; a possible association between AAT accumulation in the liver and pancreatic adenocarcinoma.
F Callea; P Goddeeris; R B Mukunda; K Geboes; J Bekaert; V J Desmet
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Applied pathology     Volume:  1     ISSN:  0252-1172     ISO Abbreviation:  Appl Pathol     Publication Date:  1983  
Date Detail:
Created Date:  1984-10-02     Completed Date:  1984-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308921     Medline TA:  Appl Pathol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  290-300     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / metabolism*,  pathology
Carcinoma / metabolism*,  pathology
Liver / metabolism*,  pathology
Middle Aged
Pancreas / pathology
Pancreatic Neoplasms / metabolism*,  pathology
Staining and Labeling
alpha 1-Antitrypsin / metabolism*
Reg. No./Substance:
0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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