| Presence of age-associated low-grade inflammation does not worsen the body response to bacterial infection in old male rats. | |
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MedLine Citation:
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PMID: 20924673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the field of frailty, there is an underlying hypothesis that chronic low-grade inflammation contributes to bad outcomes in response to a stressor. The host response to an Escherichia coli infection was assessed in 24 month old male rats exhibiting a chronic low-grade inflammation and in non-inflamed control rats. Mortality, weight loss and sarcopenia were the main outcomes measured. The presence of chronic low-grade inflammation did not affect post-infection mortality, body weight loss and tissue mass decreases. Infection-induced modifications of plasma acute phase proteins concentrations were not higher in low-grade inflamed than non-inflamed rats. Absolute synthesis rates of tissue proteins were independent of the initial inflammatory status, except for liver 10 days after infection. Altogether, age-associated chronic low-grade inflammation in male rats did not worsen the body response to bacterial infection. These results suggest that chronic low-grade inflammation is not an aggravating factor of the spiraling process leading to frailty. |
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Authors:
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Gilles Mayot; Karine Vidal; Carole Migné; Denis Breuillé; Stephanie Blum; Christiane Obled; Isabelle Papet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-06 |
Journal Detail:
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Title: Biogerontology Volume: 12 ISSN: 1573-6768 ISO Abbreviation: Biogerontology Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-24 Completed Date: 2011-07-01 Revised Date: 2013-04-24 |
Medline Journal Info:
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Nlm Unique ID: 100930043 Medline TA: Biogerontology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 133-45 Citation Subset: IM |
Affiliation:
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Unité de Nutrition Humaine, INRA, Centre Clermont-Ferrand-Theix, UMR Nutrition Humaine, Saint-Genès-Champanelle, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Aging / physiology* Animals Bacterial Infections / pathology, physiopathology* Chronic Disease Female Frail Elderly Humans Inflammation / pathology, physiopathology* Male Organ Size Proteins / metabolism Rats Rats, Wistar Receptors, Tumor Necrosis Factor, Type I / immunology Survival Rate Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Tnfrsf1a protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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