| Presence of Viral Nucleic Acids in the Middle Ear: Acute Otitis Media Pathogen or Bystander? | |
| | |
MedLine Citation:
|
PMID: 22173136 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Viruses play an important role in acute otitis media (AOM) pathogenesis and live viruses may cause AOM in absence of pathogenic bacteria. Detection of AOM pathogens generally relies on bacterial culture of middle ear fluid. When viral culture is used and live viruses are detected in the middle ear fluid of children with AOM, the viruses are generally accepted as AOM pathogens. Because viral culture is not sensitive and does not detect the comprehensive spectrum of respiratory viruses, polymerase chain reaction (PCR) assays are commonly used to detect viral nucleic acids in the middle ear fluid. While PCR assays have greatly increased the viral detection rate, new questions arise on the significance of viral nucleic acids detected in the middle ear because nucleic acids of multiple viruses are detected simultaneously, and nucleic acids of specific viruses are detected repeatedly and in a high proportion of asymptomatic children. This article first reviews the role of live viruses in AOM and presents the point-counter point arguments on whether viral nucleic acids in the middle ear represent an AOM pathogen or a bystander status. While there is evidence to support both directions, helpful information for interpretation of the data and future research direction are outlined. |
| | |
Authors:
|
Tasnee Chonmaitree; Aino Ruohola; J Owen Hendley |
Related Documents
:
|
20156676 - Volatile organic acid adsorption and cation dissociation by porphyritic andesite for en... 18758966 - Hydroxypropyl methylcellulose acetate succinate: potential drug-excipient incompatibility. 18477306 - Prediction of rabbit caecal fermentation characteristics from faeces by in vitro gas pr... 1592976 - Assessment of the effects of dentifrices on plaque acidogenesis via intra-oral measurem... 336606 - Inhibitory action of a non-metabolizable fatty acid on the growth of escherichia coli: ... 19207606 - Urates in uric acid renal calculi. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-14 |
Journal Detail:
|
Title: The Pediatric infectious disease journal Volume: - ISSN: 1532-0987 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1From the Departments of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA 2Turku University Hospital, Turku, Finland 3University of Virginia Health System, Charlottesville, VA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical Features of Infants Hospitalized for 2009 Pandemic Influenza A (H1N1) in Japan: Analysis U...
Next Document: Clinical Presentation of Invasive Pneumococcal Disease in Spain in the Era of Heptavalent Conjugate ...