Document Detail

Presence of Nano-Sized Silica During In Vitro Digestion of Foods Containing Silica as a Food Additive.
MedLine Citation:
PMID:  22364219     Owner:  NLM     Status:  Publisher    
The presence, dissolution, agglomeration state and release of materials in the nano-size range from food containing engineered nanoparticles during human digestion is a key question for the safety assessment of these materials. We used an in vitro model to mimic the human digestion. Food products subjected to in vitro digestion included (i) hot water, (ii) coffee with powdered creamer, (iii) instant soup, and (iv) pancake which either contained silica as the food additive E551, or to which a form of synthetic amorphous silica or 32 nm-SiO2 particles were added. The results showed that in the mouth stage of the digestion, nano-sized silica particles with a size range of 5-50 and 50 - 500 nm were present in food products containing E551 or added synthetic amorphous silica. However, during the successive gastric digestion stage this nano-sized silica was no longer present for the food matrices coffee and instant soup, while low amounts were found for pancakes. Additional experiments showed that the absence of nano-sized silica in the gastric stage can be contributed to an effect of the low pH combined with high electrolyte concentrations in the gastric digestion stage. Large silica agglomerates are formed under these conditions as determined by DLS and SEM experiments and explained theoretically by the extended DLVO theory. Importantly, in the subsequent intestinal digestion stage the nano-sized silica particles reappeared again, even in amounts higher than in the saliva (mouth) digestion stage. These findings suggest that upon consumption of foods containing E551, the gut epithelium is most likely exposed to nano-sized silica.
Ruud Peters; Evelien Kramer; Agnes G Oomen; Zahira E Herrera Rivera; Gerlof Oegema; Peter C Tromp; Remco Fokkink; Anton Rietveld; Hans J P Marvin; Stefan Weigel; Ad A C M Peijnenburg; Hans Bouwmeester
Related Documents :
25466669 - Differential modulation of endogenous cannabinoid cb1 and cb2 receptors in spontaneous ...
10457109 - Allergy to goat and sheep cheese with good tolerance to cow cheese.
7085289 - 129i in missouri thyroids.
23353029 - Daytime sleepiness affects prefrontal regulation of food intake.
24732669 - Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food...
23578759 - Allured or alarmed: counteractive control responses to food temptations in the brain.
17039279 - Reduction of aflatoxin b1 in chicken feed by using saccharomyces cerevisiae, rhizopus o...
25449199 - Steviol glycoside safety: are highly purified steviol glycoside sweeteners food allergens?
15333719 - In vivo imaging of intragastric gelation and its effect on satiety in humans.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-24
Journal Detail:
Title:  ACS nano     Volume:  -     ISSN:  1936-086X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101313589     Medline TA:  ACS Nano     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin.
Next Document:  Hexoctahedral Au Nanocrystals with High-index Facets and Their Optical and Surface-Enhanced Raman Sc...