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Presence of IL-9 in Paired Samples of Human Colostrum and Transitional Milk.
MedLine Citation:
PMID:  23277461     Owner:  NLM     Status:  In-Data-Review    
Background: Human colostrum and breast milk are known to contain high levels of cytokines, cytokine receptors, and chemokines. Objective: To investigate the presence and compare levels of soluble cytokines in paired samples of human colostrum and milk. Methods: Levels of 27 cytokines were measured in 9 paired samples of human colostrum (day 2 after delivery) and breast milk (day 4 or 5 after delivery) by using multiplex technology. Results: The majority of cytokines and chemokines investigated have been previously described in colostrum and/or breast milk. For the first time, we describe the presence of IL-9 in both human colostrum and milk. Of the 27 cytokines investigated, only IL-5 was absent in both colostrum and milk, whereas IL-1β, IL-2, IL-4, IL-15, IL-17, and MIP-1α were present in colostrum, but not in breast milk. In general, colostrum contained higher concentrations of cytokines with respect to human milk. Conclusion: Our data confirm and expand previous studies showing that human colostrum and breast milk are rich in cytokines and chemokines, including IL-9, which might contribute to the development of the immune system of the newborn.
Annalisa Marcuzzi; Liza Vecchi Brumatti; Lorenzo Caruso; Marco Copertino; Riccardo Davanzo; Oriano Radillo; Manola Comar; Lorenzo Monasta
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of human lactation : official journal of International Lactation Consultant Association     Volume:  29     ISSN:  1552-5732     ISO Abbreviation:  J Hum Lact     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709498     Medline TA:  J Hum Lact     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-31     Citation Subset:  N    
1Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.
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