| Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. | |
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MedLine Citation:
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PMID: 20810157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Nasal polyps often are associated with asthma. The phenotype of these patients is unknown. OBJECTIVE: To identify the mucosal factors associated with asthma comorbidity, we analyzed the inflammatory patterns of nasal polyps. METHODS: Nasal polyps from 70 Belgian patients, 34% with asthma, were analyzed for type of inflammation, T-cell cytokines, and IgE antibodies to Staphylococcus aureus enterotoxins. The same investigations were repeated in 93 Chinese patients with polyps, a group with a low asthma comorbidity rate (8%). RESULTS: In Belgian patients with polyps, 54% of samples showed eosinophilic inflammation. A classification tree evaluation identified IL-5 as the main positive determinant. Enterotoxin IgE in tissue (37%) was associated with significantly increased total IgE and eosinophil cationic protein concentrations. Expression of enterotoxin IgE, total IgE at greater than 1,442 kU/L, and eosinophil cationic protein at greater than 17,109 μg/L in samples with a total IgE concentration of greater than 246 kU/L significantly predicted asthma (odds ratio, 5.8-13). Only 7.5% of the samples from Chinese patients with polyps showed eosinophilic inflammation. IL-5 was confirmed as a positive determinant of eosinophilic inflammation, and enterotoxin IgE in tissue (17% of patients) was associated with significantly increased total IgE and eosinophil cationic protein concentrations. The expression of IL-5 or total IgE at greater than 790 kU/L in samples with an IL-5 concentration of greater than 194 pg/mL significantly predicted comorbid asthma (odds ratio, 17.2-96). CONCLUSION: Mucosal inflammation in nasal polyps orchestrated by T(H)2 cytokines and amplified by S aureus enterotoxins is characterized by an increased eosinophilic inflammation and formation of IgE antibodies. This phenotype is associated with comorbid asthma in white and Asian patients with nasal polyps. |
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Authors:
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Claus Bachert; Nan Zhang; Gabriele Holtappels; Lizzy De Lobel; Paul van Cauwenberge; Shixi Liu; Ping Lin; Jean Bousquet; Kristel Van Steen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 126 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2010-12-10 Revised Date: 2011-06-16 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 962-8, 968.e1-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Upper Airway Research Laboratory, Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent, Belgium. claus.bachert@ugent.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Asthma / epidemiology, immunology*, pathology Child Comorbidity Enterotoxins / immunology* Female Humans Immunoglobulin E / immunology* Inflammation / immunology, pathology Interleukin-5 / immunology* Male Middle Aged Nasal Polyps / epidemiology, immunology*, pathology Staphylococcus aureus / immunology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Enterotoxins; 0/IL5 protein, human; 0/Interleukin-5; 37341-29-0/Immunoglobulin E |
| Comments/Corrections | |
Comment In:
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J Allergy Clin Immunol. 2011 May;127(5):1312-3; author reply 1313-4
[PMID:
21397309
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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