Document Detail


Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
MedLine Citation:
PMID:  20810157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nasal polyps often are associated with asthma. The phenotype of these patients is unknown.
OBJECTIVE: To identify the mucosal factors associated with asthma comorbidity, we analyzed the inflammatory patterns of nasal polyps.
METHODS: Nasal polyps from 70 Belgian patients, 34% with asthma, were analyzed for type of inflammation, T-cell cytokines, and IgE antibodies to Staphylococcus aureus enterotoxins. The same investigations were repeated in 93 Chinese patients with polyps, a group with a low asthma comorbidity rate (8%).
RESULTS: In Belgian patients with polyps, 54% of samples showed eosinophilic inflammation. A classification tree evaluation identified IL-5 as the main positive determinant. Enterotoxin IgE in tissue (37%) was associated with significantly increased total IgE and eosinophil cationic protein concentrations. Expression of enterotoxin IgE, total IgE at greater than 1,442 kU/L, and eosinophil cationic protein at greater than 17,109 μg/L in samples with a total IgE concentration of greater than 246 kU/L significantly predicted asthma (odds ratio, 5.8-13). Only 7.5% of the samples from Chinese patients with polyps showed eosinophilic inflammation. IL-5 was confirmed as a positive determinant of eosinophilic inflammation, and enterotoxin IgE in tissue (17% of patients) was associated with significantly increased total IgE and eosinophil cationic protein concentrations. The expression of IL-5 or total IgE at greater than 790 kU/L in samples with an IL-5 concentration of greater than 194 pg/mL significantly predicted comorbid asthma (odds ratio, 17.2-96).
CONCLUSION: Mucosal inflammation in nasal polyps orchestrated by T(H)2 cytokines and amplified by S aureus enterotoxins is characterized by an increased eosinophilic inflammation and formation of IgE antibodies. This phenotype is associated with comorbid asthma in white and Asian patients with nasal polyps.
Authors:
Claus Bachert; Nan Zhang; Gabriele Holtappels; Lizzy De Lobel; Paul van Cauwenberge; Shixi Liu; Ping Lin; Jean Bousquet; Kristel Van Steen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  126     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2010-12-10     Revised Date:  2011-06-16    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  962-8, 968.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
Upper Airway Research Laboratory, Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent, Belgium. claus.bachert@ugent.be
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Asthma / epidemiology,  immunology*,  pathology
Child
Comorbidity
Enterotoxins / immunology*
Female
Humans
Immunoglobulin E / immunology*
Inflammation / immunology,  pathology
Interleukin-5 / immunology*
Male
Middle Aged
Nasal Polyps / epidemiology,  immunology*,  pathology
Staphylococcus aureus / immunology*
Young Adult
Chemical
Reg. No./Substance:
0/Enterotoxins; 0/IL5 protein, human; 0/Interleukin-5; 37341-29-0/Immunoglobulin E
Comments/Corrections
Comment In:
J Allergy Clin Immunol. 2011 May;127(5):1312-3; author reply 1313-4   [PMID:  21397309 ]

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