| The presence of histidine-rich glycoprotein in the female reproductive tract and in embryos. | |
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MedLine Citation:
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PMID: 20639474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A well-regulated angiogenesis is crucial for proper embryo implantation, embryogenesis, and pregnancy development. Monitoring the presence and distribution of angiogenic regulators in the female reproductive tract and in the early embryo is important for a broader understanding of the molecular aspects of fertility, embryogenesis, and pregnancy. Histidine-rich glycoprotein (HRG) is a glycoprotein involved in angiogenesis. Its presence in the female reproductive tract or in embryos has not previously been studied. Follicular fluid, culture medium, and embryos were obtained from patients undergoing in vitro fertilization (IVF). Biopsies from inner genitalia and placenta were collected at surgery. Histidine-rich glycoprotein presence was investigated by immunohistochemistry and Western blot. Polymerase chain reaction (PCR) was used to determine HRG expression in tissues or by embryos. We identified HRG in follicular fluid, the female reproductive tract, and placenta, as well as in the embryos. Moreover, HRG expression was observed in blastocysts. Thus, the angiogenic properties of HRG might affect fertility. |
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Authors:
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Sarah Nordqvist; Karin Kårehed; Fredwell Hambiliki; Kjell Wånggren; Anneli Stavreus-Evers; Helena Akerud |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-16 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 17 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 941-7 Citation Subset: IM |
Affiliation:
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Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Blastocyst / metabolism* Embryonic Development / physiology* Female Follicular Fluid / metabolism Genitalia, Female / metabolism* Humans Immunohistochemistry Placenta / metabolism* Pregnancy Proteins / genetics, metabolism* RNA / chemistry, genetics Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 0/histidine-rich proteins; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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