Document Detail


Presence of Borrelia burgdorferi sensu lato antibodies in the serum of patients with abdominal aortic aneurysms.
MedLine Citation:
PMID:  21842293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infectious agents are likely to play a role in the pathogenesis of chronic inflammatory diseases, including abdominal aortic aneurysms (AAAs). The goal of this study was to determine if Borrelia burgdorferi sensu lato (sl), a microorganism responsible for Lyme disease, is involved in the etiology of AAAs. The presence of serum antibodies against B. burgdorferi sl was measured with enzyme-linked immunosorbent assay (ELISA) and confirmed by Western blotting in 96 AAA and 108 peripheral artery disease (PAD) patients. Polymerase chain reaction (PCR) was used for the detection of Borrelia-specific DNA in the aneurysm wall. Among AAA patients 34% and among PAD patients 16% were seropositive for B. burgdorferi sl antibodies (Fisher's exact test, p = 0.003; odds ratio [OR] 2.79; 95% confidence interval [CI] 1.37-5.85). In the German general population, 3-17% are seropositive for Borrelia antibodies. No Borrelia DNA was detected in the aneurysm wall. Our findings suggest a relationship between AAAs and B. burgdorferi sl. We hypothesize that the underlying mechanism for B. burgdorferi sl in AAA formation is similar to that by the spirochete Treponema pallidum; alternatively, AAAs could develop due to induced autoimmunity via molecular mimicry due to similarities between some of the B. burgdorferi sl proteins and aortic proteins.
Authors:
I Hinterseher; G Gäbel; F Corvinus; C Lück; H D Saeger; H Bergert; G Tromp; H Kuivaniemi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-13
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  31     ISSN:  1435-4373     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-05     Completed Date:  2012-07-25     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  781-9     Citation Subset:  IM    
Affiliation:
Department of Visceral, Thoracic, and Vascular Surgery, Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany. irene.hinterseher@uniklinikum-dresden.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Antibodies, Bacterial / blood*
Aortic Aneurysm, Abdominal / epidemiology*,  etiology*
Blotting, Western
Borrelia burgdorferi Group / immunology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lyme Disease / complications*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial
Comments/Corrections

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