Document Detail

Prescriptions filled during pregnancy for drugs with the potential of fetal harm.
MedLine Citation:
PMID:  19832828     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the extent of prescriptions filled by pregnant women for drugs with recognised potential of fetal harm, and to document the outcomes of these pregnancies. DESIGN: Cross-sectional study. POPULATION: Quebec Pregnancy Registry. METHODS: We identified women who were pregnant during a five-year period and who were insured for prescription medications under the provincial drug plan. We obtained information on prescriptions filled during pregnancy for drugs with known potential of fetal harm. MAIN OUTCOME MEASURES: Prescriptions filled for study drugs during the first, second and third trimesters of pregnancy; termination of pregnancy (TOP) or delivery, and whether the baby was diagnosed with a major congenital malformation (MCM). RESULTS: Of 109 344 women, 56% filled at least one prescription for a medication during pregnancy; 6.3% filled at least one prescription for a drug known to pose a risk to the fetus. Overall, 47% (95% CI, 45.8-48.2) of pregnancies exposed to drugs under study ended in TOP versus 36.2% (95% CI, 35.9-36.5) of those not exposed; 8.2% (95% CI, 8.0-10.0) of live births were diagnosed with an MCM during the first year of life versus 7.1% (95% CI, 6.9-7.3) of those not exposed. CONCLUSIONS: This study documents an important level of prescriptions filled during pregnancy for drugs harmful to the developing fetus. The proportions of both TOPs and babies born with MCMs were elevated compared with the expected values. Clinicians caring for women during pregnancy should conduct a medication inventory prior to a planned pregnancy, or as soon as an unplanned pregnancy is recognised.
S Kulaga; A H Zargarzadeh; A Zagarzadeh; A Bérard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-13
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  116     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2010-01-28     Revised Date:  2010-01-30    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1788-95     Citation Subset:  AIM; IM    
Faculty of Pharmacy, University of Montreal, Montréal, QC, Canada.
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology,  etiology*
Cross-Sectional Studies
Drug Prescriptions / statistics & numerical data*
Infant, Newborn
Maternal-Fetal Exchange
Middle Aged
Pregnancy Complications / drug therapy*
Pregnancy Outcome
Quebec / epidemiology
Young Adult
Reg. No./Substance:
Erratum In:
BJOG. 2010 Feb;117(3):373
Note: Zagarzadeh, A [corrected to Zargarzadeh, A H]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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