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Prescription of teriparatide in the UK - a nationwide register study from 2004 to 2008.
MedLine Citation:
PMID:  21726012     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The objectives were to ascertain the incidence of teriparatide prescription in the UK stratified by region and sex, examine the association between National Institute for Health and Clinical Excellence (NICE) and European Medicines Agency approval and geographic variation in teriparatide prescription, and compare the regional rates of teriparatide and oral bisphosphonate use. METHODS: Healthcare at Home provided anonymized information on age, sex, year, and treating hospital for all UK residents commenced on teriparatide between 1 January 2004 and 31 December 2008. The crude and age- and sex-adjusted rates of teriparatide prescription were calculated for each region. Rates of teriparatide prescription for each region, in the year before and in the year after approval by NICE and European Medicines Agency, were compared in a multiplicative model (likelihood-ratio test) for women and men, respectively. The number of patients on oral bisphosphonates in each region was estimated from quantity of oral bisphosphonates dispensed in 2007. RESULTS: Compared with that in England, the incidence of teriparatide prescription was 54% and 50% higher in Wales and in Scotland, respectively. The Northeast and East of England had lowest rate of teriparatide use. There was significant geographic variation in increase in teriparatide prescription in women after favorable NICE recommendation (p = 0.0001). In contrast, prescription rates in men increased uniformly across the UK (p = 0.15). Geographic variation in oral bisphosphonate prescription did not mirror that of teriparatide. CONCLUSION: We report wide geographic variation in teriparatide prescription rates within the UK. In a country with government-funded health care, reasons for this inequality need to be identified. Copyright © 2011 John Wiley & Sons, Ltd.
Authors:
Abhishek Abhishek; Ira Pande; Richard B Hubbard
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-1
Journal Detail:
Title:  Pharmacoepidemiology and drug safety     Volume:  -     ISSN:  1099-1557     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208369     Medline TA:  Pharmacoepidemiol Drug Saf     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Affiliation:
Department of Rheumatology, Nottingham University Hospital, Nottingham, Nottinghamshire, UK; Academic Rheumatology, Clinical Sciences Building, City Hospital Nottingham, Nottingham, Nottinghamshire, UK. docabhishek.@gmail.com.
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