Document Detail

Prescription drug use among pregnant women in Opioid Maintenance Treatment.
MedLine Citation:
PMID:  22882166     Owner:  NLM     Status:  Publisher    
AIM: This study describes the use of prescribed drugs among women in Opioid Maintenance Treatment (OMT) prior to and during pregnancy. DESIGN: This cohort study was based on data from two nationwide databases: the Medical Birth Registry of Norway and the Norwegian Prescription Database. SETTING: Norway, 2004-2010. PARTICIPANTS: OMT drugs were dispensed to 138 women with 159 pregnancies. MEASUREMENTS: All prescription drugs dispensed to women in OMT three months prior to and during pregnancy were studied. Amounts of benzodiazepines, z-hypnotics and opioid analgesics dispensed during pregnancy were studied and bivariate analysis were used to study neonatal outcomes of OMT pregnancies with and without such co-medication. FINDINGS: The prevalence of prescription drug use by pregnant OMT women was high both during the three months period prior to (69%) and during (81%) pregnancy. The proportion of pregnant women who were dispensed antiinfectives (48%) and/or drugs acting on the nervous system (45%) during any time in pregnancy was especially high. In 21, 15 and 13 % of the pregnancies the women were dispensed benzodiazepine anxiolytics, opioid analgesics or benzodiazepine hypnotics respectively. Only 5% of the OMT women were dispensed antidepressants. Malformations were significantly more common among children born to mothers in OMT that received co-medication with opioids, benzodiazepines or z-hypnotics. CONCLUSIONS: A higher proportion of women in Opioid Maintenance Treatment in Norway use prescription drugs prior to and during pregnancy than pregnant women in the general population. Co-medication with drugs with abuse potential may increase the risk of adverse pregnancy outcomes and this need to be further addressed.
Ingunn Olea Lund; Marte Handal; Anders Engeland; Kari Furu; Edle Ravndal; Svetlana Skurtveit
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  Addiction (Abingdon, England)     Volume:  -     ISSN:  1360-0443     ISO Abbreviation:  Addiction     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304118     Medline TA:  Addiction     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author, Addiction © 2012 Society for the Study of Addiction.
SERAF - Norwegian Centre for Addiction Research, University of Oslo, Oslo, Norway.
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