| Prescribing of smoking cessation medication in England since the introduction of varenicline. | |
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MedLine Citation:
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PMID: 21395894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To estimate the effect of the introduction of a new smoking cessation medication, varenicline, and the publication of guidance related to its use, on trends in prescribing of smoking cessation medications in England. DESIGN: Interrupted time series analysis of primary care data on prescribing of smoking cessation medication using autoregressive integrated moving average (ARIMA) modelling. SETTING: A total of 446 general practices included in The Health Improvement Network (THIN), a database of UK electronic primary care records. PARTICIPANTS: All primary care patients registered with a THIN practice in England. MEASUREMENTS: Monthly rates of prescribing of varenicline, nicotine replacement therapy (NRT) and bupropion per 100 000 patients registered with a THIN practice between June 2000 and June 2009. FINDINGS: NRT was the most commonly prescribed stop smoking medication, and bupropion the least frequently prescribed. After its introduction in December 2006 varenicline rapidly became the second most commonly prescribed drug. There was no statistically significant change in overall prescribing for smoking cessation medications after its introduction (P = 0.760), or after the publication of the related guidance in July 2007 (P = 0.134). CONCLUSIONS: Soon after being introduced in England, varenicline was widely prescribed; after nicotine replacement therapy it was the most commonly prescribed cessation medication. However, this does not appear to have increased overall rates of prescribing for smoking cessation medication. |
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Authors:
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Tessa E Langley; Yue Huang; Ann McNeill; Tim Coleman; Lisa Szatkowski; Sarah Lewis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-05-03 |
Journal Detail:
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Title: Addiction (Abingdon, England) Volume: 106 ISSN: 1360-0443 ISO Abbreviation: Addiction Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-03 Completed Date: 2011-09-20 Revised Date: 2011-10-21 |
Medline Journal Info:
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Nlm Unique ID: 9304118 Medline TA: Addiction Country: England |
Other Details:
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Languages: eng Pagination: 1319-24 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors, Addiction © 2011 Society for the Study of Addiction. |
Affiliation:
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UK Centre for Tobacco Control Studies, Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK. tessa.langley@nottingham.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzazepines
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therapeutic use* Bupropion / therapeutic use Dopamine Uptake Inhibitors / therapeutic use Drug Prescriptions / statistics & numerical data Electronic Health Records / statistics & numerical data England Family Practice / statistics & numerical data Humans Models, Statistical* Nicotine / therapeutic use Nicotinic Agonists / therapeutic use* Physician's Practice Patterns / trends* Practice Guidelines as Topic Quinoxalines / therapeutic use* Smoking / legislation & jurisprudence, prevention & control Smoking Cessation / methods, statistics & numerical data* State Medicine Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Cancer Research UK; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Dopamine Uptake Inhibitors; 0/Nicotinic Agonists; 0/Quinoxalines; 0/varenicline; 34841-39-9/Bupropion; 54-11-5/Nicotine |
| Comments/Corrections | |
Comment In:
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Addiction. 2011 Oct;106(10):1868-9; author reply 1869
[PMID:
21793957
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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