Document Detail


Prescribing for older people with chronic renal impairment.
MedLine Citation:
PMID:  23529455     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Renal function is an important prescribing consideration. On average, glomerular filtration rate declines by about 10 mL/min every 10 years after the age of 40. Renal impairment may cause medicines to accumulate or cause toxicity, especially if the medicine has a narrow therapeutic index.
OBJECTIVE: To present an overview of prescribing considerations in the primary care setting for patients with chronic renal impairment.
DISCUSSION: Serum creatinine considered in isolation is not a reliable indicator of renal function. The estimated glomerular filtration rate provided in pathology reporting can alert prescribers to possible renal impairment and the need to consider dose adjustments. The Cockcroft-Gault equation should be used to adjust medicine doses. Renal function monitoring is recommended for patients using medicines that can impair renal function or cause nephrotoxicity (eg. NSAIDs, ACEIs, ARBs).
Authors:
J Simon Bell; Natalie Blacker; V Tammy Leblanc; Christopher P Alderman; Adam Phillips; Debra Rowett; Simone Rossi; Oliver Frank; Alan Husband
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian family physician     Volume:  42     ISSN:  0300-8495     ISO Abbreviation:  Aust Fam Physician     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-03-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326701     Medline TA:  Aust Fam Physician     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Affiliation:
BPharm(Hons), PhD, MPS, is Associate Professor, Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia.
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