Document Detail

Prescribing for older people with chronic renal impairment.
MedLine Citation:
PMID:  23529455     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Renal function is an important prescribing consideration. On average, glomerular filtration rate declines by about 10 mL/min every 10 years after the age of 40. Renal impairment may cause medicines to accumulate or cause toxicity, especially if the medicine has a narrow therapeutic index.
OBJECTIVE: To present an overview of prescribing considerations in the primary care setting for patients with chronic renal impairment.
DISCUSSION: Serum creatinine considered in isolation is not a reliable indicator of renal function. The estimated glomerular filtration rate provided in pathology reporting can alert prescribers to possible renal impairment and the need to consider dose adjustments. The Cockcroft-Gault equation should be used to adjust medicine doses. Renal function monitoring is recommended for patients using medicines that can impair renal function or cause nephrotoxicity (eg. NSAIDs, ACEIs, ARBs).
J Simon Bell; Natalie Blacker; V Tammy Leblanc; Christopher P Alderman; Adam Phillips; Debra Rowett; Simone Rossi; Oliver Frank; Alan Husband
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian family physician     Volume:  42     ISSN:  0300-8495     ISO Abbreviation:  Aust Fam Physician     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-03-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326701     Medline TA:  Aust Fam Physician     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
BPharm(Hons), PhD, MPS, is Associate Professor, Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia.
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