Document Detail


Preputialectomised and intact adult male mice exhibit an elevated urinary ratio of oestradiol to creatinine in the presence of developing females, whilst promoting uterine and ovarian growth of these females.
MedLine Citation:
PMID:  19698290     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure to novel adult males and their urine can hasten the onset of sexual maturity in female mice. Some evidence implicates chemosignals from males' preputial glands, while other evidence suggests that male urinary steroids, especially 17beta-oestradiol, contribute to this effect. The present experiment was designed to determine whether preputial gland removal would influence the capacity of males to accelerate female sexual development, and to measure male urinary oestradiol and testosterone in the presence or absence of these glands. Juvenile females aged 28 days were housed for two weeks in isolation or underneath two outbred males that had undergone preputialectomy or sham surgery. Urine samples were collected non-invasively from males that were isolated or exposed to females, then assayed for oestradiol, testosterone and creatinine. Combined uterine and ovarian mass from females sacrificed at 43 days of age was increased by exposure to males, regardless of whether or not these males had been preputialectomised. Male urinary creatinine was reduced by exposure to developing females. Creatinine-adjusted oestradiol and testosterone were significantly greater in female-exposed than in isolated males, in both preputialectomised and intact males. These data suggest that the preputials are not necessary for the capacity of males to hasten female uterine and ovarian growth. As exogenous oestrogens can promote uterine growth and other parameters of female reproductive maturation, oestradiol in males' urine may contribute to earlier sexual maturity in male-exposed females.
Authors:
Ayesha Khan; Robert G Berger; Denys Decatanzaro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  21     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  860-8     Citation Subset:  IM    
Affiliation:
Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Creatinine / urine*
Estradiol / urine*
Female
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Ovary / growth & development*,  metabolism
Pheromones / secretion*
Scent Glands / secretion,  surgery*
Sexual Maturation*
Social Behavior
Social Environment
Testosterone / urine
Uterus / growth & development*,  metabolism
Chemical
Reg. No./Substance:
0/Pheromones; 50-28-2/Estradiol; 58-22-0/Testosterone; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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