| Prepubertal primordial follicle loss in mice is not due to classical apoptotic pathways. | |
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MedLine Citation:
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PMID: 19264701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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More than half of the primordial follicles that are formed by Day 6 of postnatal life in the mouse will be eliminated from the ovary by the time of puberty. Apoptosis, a form of programmed cell death, is one mechanism by which these follicles could be actively lost. To investigate whether apoptosis is responsible for the loss of primordial follicles, follicular atresia was examined during the prepubertal period, when follicles die and are cleared from the ovary at an extremely high rate. Four hallmarks of classical apoptosis were measured in follicles present in prepubertal ovaries. The primordial follicle cohort was not positively associated with nuclear condensation or cell shrinkage, activation of caspase 3, cleavage of poly(ADP ribose) polymerase 1 (PARP1), or fragmentation of DNA. These data are consistent with a nonapoptotic pathway that is responsible for small follicle death. |
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Authors:
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Candace M Tingen; Sarah K Bristol-Gould; Sarah E Kiesewetter; Jason Tyler Wellington; Lonnie Shea; Teresa K Woodruff |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-03-04 |
Journal Detail:
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Title: Biology of reproduction Volume: 81 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-26 Completed Date: 2009-09-22 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: United States |
Other Details:
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Languages: eng Pagination: 16-25 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology* Caspases / metabolism Cell Count / methods Cell Death Female Mice Models, Biological Models, Theoretical Ovarian Follicle / cytology, metabolism, physiology* Sexual Maturation / physiology* Signal Transduction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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P01 HD 21921/HD/NICHD NIH HHS; P01 HD021921-209001/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.4.22.-/Caspases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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