| Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury. | |
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MedLine Citation:
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PMID: 12684214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired lung function in severe acute pancreatitis is the primary cause of morbidity and mortality in this condition. Preprotachykinin-A (PPT-A) gene products substance P and neurokinin (NK)-A have been shown to play important roles in neurogenic inflammation. Substance P acts primarily (but not exclusively) via the NK1 receptor. NKA acts primarily via the NK2 receptor. Earlier work has shown that knockout mice deficient in NK1 receptors are protected against acute pancreatitis and associated lung injury. NK1 receptors, however, bind other peptides in addition to substance P, not all of which are derived from the PPT-A gene. To examine the role of PPT-A gene products in acute pancreatitis, the effect of PPT-A gene deletion on the severity of acute pancreatitis and the associated lung injury was investigated. Deletion of PPT-A almost completely protected against acute pancreatitis-associated lung injury, with a partial protection against local pancreatic damage. These results show that PPT-A gene products are critical proinflammatory mediators in acute pancreatitis and the associated lung injury. |
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Authors:
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Madhav Bhatia; John Slavin; Yuqing Cao; Allan I Basbaum; John P Neoptolemos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 284 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-09 Completed Date: 2003-05-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G830-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, National University of Singapore, Singapore 117597. mbhatia@nus.edu.sg |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amylases / metabolism Animals Caerulein / pharmacology Dose-Response Relationship, Drug Gene Deletion* Lung / metabolism, pathology Lung Diseases / complications*, genetics*, pathology Mice Mice, Knockout Pancreas / metabolism, pathology Pancreatitis / complications*, genetics*, pathology Protein Precursors / genetics*, metabolism* Tachykinins / genetics*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Protein Precursors; 0/Tachykinins; 0/preprotachykinin; 17650-98-5/Caerulein; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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