Document Detail


Preprogramming and control activity of bimanual self-paced motor task in Parkinson's disease.
MedLine Citation:
PMID:  10802459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The authors investigated programming (Bereitschaftspotential or BP) and control activity (Skilled Performance Positivity or SPP) of a bimanual, sequential, skilled motor act in off-therapy Parkinson's disease (PD) patients. METHODS: We recorded Movement Related Potentials (MRPs) in 12, non-demented, off-therapy parkinsonian patients and in 17 control subjects who were performing a skilled, time-locked motor act, which was not routine in their everyday life but had to be learned: the Skilled Performance Task (SPT). BP, SPP and correct performances were evaluated in grand average waveforms and in sequential blocks. RESULTS: The analysis of correct performances showed that accuracy in PD patients was significantly lower than in the control group and this accuracy did not improve throughout the blocks. A significantly low level of performances was associated with an increased BP amplitude (P<0.05) and decreased SPP amplitude (P<0.05) in PD patients. CONCLUSION: Our findings suggest that skill motor learning is impaired in non-demented unmedicated PD patients. We discuss the view that PD patients may allocate more attentional resources, as suggested by the increased BP amplitude, the decreased SPP amplitude and the low correct performances, in order to perform a new skilled motor act.
Authors:
F Fattapposta; F Pierelli; G Traversa; F My; M Mostarda; C D'Alessio; G Soldati; J Osborn; G Amabile
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  111     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-14     Completed Date:  2000-07-14     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  873-83     Citation Subset:  IM    
Affiliation:
Istituto di Clinica delle Malattie Nervose e Mentali, Università degli Studi di Roma 'La Sapienza', Viale dell'Università 30, 00185, Rome, Italy. fattapposta@uniroma1.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Attention
Brain / physiology,  physiopathology*
Brain Mapping*
Electroencephalography
Electromyography
Electrooculography
Evoked Potentials, Somatosensory / physiology*
Female
Hand / innervation
Humans
Male
Middle Aged
Motor Skills / physiology
Parkinson Disease / physiopathology*
Psychomotor Performance / physiology*
Reference Values
Video Recording

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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