| Preprocedural white blood cell count as a predictor of death and major adverse cardiac events in patients undergoing percutaneous coronary intervention with drug-eluting stents. | |
| | |
MedLine Citation:
|
PMID: 19411718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Patients with elevated white blood cell (WBC) counts who undergo percutaneous coronary intervention (PCI) are at increased risk for short- and long-term mortality as well as major adverse cardiac events (MACE). We assessed the relationship between elevated WBC counts and clinical events in patients who underwent PCI with drug-eluting stents (DES). METHODS: Our retrospective study includes 878 consecutive patients who underwent both elective and emergent PCI with DES at the UCLA Medical Center. The cohort was divided into tertiles based upon the presenting WBC count: 2.8-6.3 x 109 cells/L (tertile 1 [T1]), 6.4-8.7 x 109 cells/L (tertile 2 [T2]), > or = 8.8 x 109 cells/L (tertile 3 [T3]). RESULTS: Survival at 1 year was significantly different between all three tertiles, and was poorest in patients with WBC counts in T3 (93.9%-T1, 98.4%-T2, 87.3%-T3; p < 0.0001), while T2 had the highest survival rate at 1 year. Age, chronic renal insufficiency, chronic obstructive pulmonary disease, low WBC count in T1, elevated WBC count in T3 and presentation with myocardial infarction were identified as multivariable predictors for survival at 1 year. CONCLUSION: Both elevated and low WBC counts are associated with increased mortality and MACE at 1 year following PCI with DES. WBC count is an independent predictor of survival in patients who undergo PCI with DES implantation. |
| | |
Authors:
|
Daniel L Jurewitz; Antonio Pessegueiro; Raymond Zimmer; Ravi Bhatia; Jonathan Tobis; Michael S Lee |
Related Documents
:
|
23211998 - Sequential bi-atrial linear defragmentation approach for persistent atrial fibrillation. 23532508 - Biventricular mechanics in constrictive pericarditis comparison with restrictive cardio... 18317668 - Risk predictors for adverse outcomes after percutaneous coronary interventions and thei... 18854538 - Frequency of stress testing to document ischemia prior to elective percutaneous coronar... 8439018 - The pressure rate quotient is not an indicator of myocardial ischemia in humans. an ech... 16921398 - Nupafant, a paf-antagonist prototype for suppression of ventricular fibrillation withou... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of invasive cardiology Volume: 21 ISSN: 1557-2501 ISO Abbreviation: J Invasive Cardiol Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-05-04 Completed Date: 2009-09-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 202-6 Citation Subset: IM |
Affiliation:
|
David Geffen School of Medicine at University of California, Los Angeles, Division of Cardiology, Los Angeles, California 90095, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Transluminal, Percutaneous Coronary
/
mortality* Cohort Studies Comorbidity Coronary Artery Disease / mortality, therapy* Drug-Eluting Stents* Follow-Up Studies Health Status Indicators Humans Kidney Failure, Chronic / mortality Leukocyte Count* Myocardial Infarction / mortality* Pulmonary Disease, Chronic Obstructive / mortality Retrospective Studies Risk Factors Survival Rate |
| Comments/Corrections | |
Comment In:
|
J Invasive Cardiol. 2009 May;21(5):207-8
[PMID:
19411719
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Feasibility and safety of ad hoc percutaneous coronary intervention in the modern era.
Next Document: Impact of thrombus aspiration use for the treatment of stent thrombosis on early patient outcomes.