Document Detail


Preprocedural serum levels of acute-phase reactants and prognosis after percutaneous coronary intervention.
MedLine Citation:
PMID:  14522415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In this study we evaluate the value of baseline concentrations of acute-phase reactants on prognosis after percutaneous coronary intervention (PCI). METHODS: Blood samples were drawn immediately before PCI to measure baseline concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), lipoprotein(a) (Lp(a)), and fibrinogen. Follow-up data were collected at 8 months. Repeat PCI, CABG, myocardial infarction, and death were recorded as major adverse clinical events (MACE). Furthermore the recurrence of angina pectoris was noted. RESULTS: The study included 600 consecutive patients after a successful PCI. Sixty-four percent of the patients were stented. The mean age was 61.6 years and 68.9% were male. CRP levels were significantly higher in patients who were to have repeat angina as compared with those who were not (P=0.0322). IL-6 levels were not correlated with angina or MACE. Lp(a) and fibrinogen concentrations were both significantly related to MACE (P=0.0337 and P=0.0253, respectively). CONCLUSION: Our study clearly supports the role of inflammation in restenosis after PCI as measured in statistically higher levels of Lp(a) and fibrinogen in patients with MACE and CRP in patients with repeat angina.
Authors:
Braim M Rahel; Frank L J Visseren; Maarten-Jan Suttorp; Thijs H W Plokker; Johannes C Kelder; Bartelt M de Jongh; K Paul Bouter; Rob J A Diepersloot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  60     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-02     Completed Date:  2003-12-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  136-40     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Heart Lung Center Utrecht, Location: St Antonius Hospital Nieuwegein, P.O. Box 2500, 3430 EM, Nieuwegein, The Netherlands. b.rahel@antonius.net
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / analysis*
Aged
Angioplasty, Transluminal, Percutaneous Coronary*
Biological Markers / blood
C-Reactive Protein / analysis
Coronary Disease / blood*,  mortality,  therapy*
Female
Fibrinogen / analysis
Follow-Up Studies
Humans
Interleukin-6 / blood
Lipoprotein(a) / blood
Male
Middle Aged
Prognosis
Recurrence
Stents
Survival Rate
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/Interleukin-6; 0/Lipoprotein(a); 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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