Document Detail

Prepregnancy obesity as a risk factor for structural birth defects.
MedLine Citation:
PMID:  17679655     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe the relation between maternal obesity, overweight and underweight status, and 16 categories of structural birth defects. DESIGN: An ongoing multisite, case-control study. Clinical geneticists reviewed all of the cases, excluding those that had or were strongly suspected to have a single-gene disorder or chromosomal abnormality. Mothers with preexisting diabetes were also excluded. Body mass index was based on maternal report of height and weight prior to pregnancy. SETTING: Eight participating states in the United States. PARTICIPANTS: Mothers enrolled in the National Birth Defects Prevention Study who had index pregnancies between October 1, 1997, and December 31, 2002. MAIN EXPOSURE: Maternal obesity. MAIN OUTCOME MEASURES: Crude and adjusted odds ratios. RESULTS: Mothers of offspring with spina bifida, heart defects, anorectal atresia, hypospadias, limb reduction defects, diaphragmatic hernia, and omphalocele were significantly more likely to be obese than mothers of controls, with odds ratios ranging between 1.33 and 2.10. Mothers of offspring with gastroschisis were significantly less likely to be obese than mothers of controls. CONCLUSIONS: To our knowledge, this is the first population-based study of its scale to examine prepregnancy obesity and a range of structural birth defects. These results suggest a weak to moderate positive association of maternal obesity with 7 of 16 categories of birth defects and a strong inverse association with gastroschisis. The mechanisms underlying these associations are not yet understood but may be related to undiagnosed diabetes.
D Kim Waller; Gary M Shaw; Sonja A Rasmussen; Charlotte A Hobbs; Mark A Canfield; Anna-Maria Siega-Riz; M Shayne Gallaway; Adolfo Correa;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  161     ISSN:  1072-4710     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-07     Completed Date:  2007-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  745-50     Citation Subset:  AIM; IM    
School of Public Health, The University of Texas at Houston, Houston, TX 77030, USA.
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MeSH Terms
Body Mass Index
Case-Control Studies
Congenital Abnormalities / classification,  epidemiology,  etiology*
Health Surveys
Infant, Newborn
Interviews as Topic
Maternal Welfare*
Obesity / complications*,  epidemiology
Odds Ratio
Population Surveillance
Pregnancy Complications* / epidemiology
Risk Assessment
Risk Factors
United States / epidemiology
Grant Support
U50/CCU613232//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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