| Preprandial microemulsion cyclosporine administration is effective for patients with refractory nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 19057979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: The present study evaluated the clinical efficacy and pharmacokinetics of microemulsion cyclosporine A (ME-CyA) with modification from postprandial to preprandial administration in adult patients with refractory nephrotic syndrome. METHODS: We investigated 19 patients with refractory nephrotic syndrome who had been switched from the postprandial administration of ME-CyA to preprandial administration. The pharmacokinetics of ME-CyA were also evaluated before and 6 months after switching from postprandial to preprandial administration by serial measurement of the blood CyA concentration in 10 patients. RESULTS: This study showed that 16 of 19 patients (84%) displayed an improvement in their clinical condition or continued to maintain remission after switching from post- to preprandial administration. In particular among 14 patients with minimal change nephrotic syndrome (MCNS) in this study, 13 patients maintained or achieved remission under preprandial ME-CyA administration. Only three of 10 patients with postprandial administration showed a peak concentration> 500 ng/ml within 1-2 h after administration, while with preprandial administration, nine of 10 patients showed this good absorption profiles. This effectiveness of preprandial administration seems to be dependent on the improved pharmacokinetics with the increase of area under the curve from 0-4 h (AUC(0-4)) and peak concentration. There were no statistical differences in the mean daily doses of ME-CyA between both administration periods. No ME-CyA-induced nephrotoxicity or other harmful events were encountered throughout the study. CONCLUSION: The preprandial administration of ME-CyA results in a good pharmacokinetic profile and is useful for management of refractory nephrotic syndrome in adults, particularly in patients with MCNS. |
| | |
Authors:
|
Sayuri Shirai; Takashi Yasuda; Hiroki Tsuchida; Shingo Kuboshima; Yusuke Konno; Yoshinori Shima; Takeo Sato; Shigeo Hatta; Keisou Masuhara; Kenjirou Kimura |
Related Documents
:
|
9353969 - A case of nephrotic syndrome with rapid spontaneous remission in an elderly patient. 10975309 - Alport-like glomerular changes in a patient with nephrotic syndrome: report of a case. 19908069 - Membranous nephropathy in children: clinical presentation and therapeutic approach. 90759 - Does the nephrotic syndrome increase the risk of cardiovascular disease? 5434659 - Serological studies on nephrotic syndrome of quartan malaria in uganda. 17276499 - Abnormalities of homocysteine and b vitamins in the nephrotic syndrome. 1332359 - Clinical and pathophysiological aspects of neurological complications in renal failure. 15596209 - Dystrophic ureteral calcification associated with churg-strauss vasculitis. 9353969 - A case of nephrotic syndrome with rapid spontaneous remission in an elderly patient. |
Publication Detail:
|
Type: Clinical Trial; Journal Article Date: 2008-12-05 |
Journal Detail:
|
Title: Clinical and experimental nephrology Volume: 13 ISSN: 1342-1751 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-04-21 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
|
Languages: eng Pagination: 123-9 Citation Subset: IM |
Affiliation:
|
Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan. sirababu@marianna-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adolescent Adult Aged Cyclosporine / administration & dosage*, blood, pharmacokinetics* Emulsions Humans Immunosuppressive Agents / administration & dosage*, blood, pharmacokinetics* Intestinal Absorption* Middle Aged Nephrosis, Lipoid / drug therapy* Postprandial Period Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Emulsions; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dietary arginine supplementation enhances antioxidative capacity and improves meat quality of finish...
Next Document: Determinants for the prognosis of acute renal disorders that developed during or after treatment wit...