| Prepidil compared to Propess for cervical ripening. | |
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MedLine Citation:
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PMID: 12206922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To compare the efficacy and safety of intracervical PGE(2) gel (Prepidil) with intravaginal PGE(2) insert (Propess) in cervical ripening and induction of labour. STUDY DESIGN: This was a retrospective analysis of patients with single pregnancies, intact membranes and a viable fetus who required cervical ripening. In the first half of 1998, all patients received Prepidil and in the first half of 1999 all patients received Propess. In both periods 50 consecutive files were retrieved and compared. RESULTS: The Prepidil and Propess group were similar in patient characteristics, indication for induction of labour and delivery outcome. Cervical ripening within 24 h was achieved in the Propess group in 80% as compared to 56% in the Prepidil group. The application-membrane rupture-interval was shorter in the Propess group compared to the Prepidil group (23.7 +/- 21.3 h versus 56.4 +/- 77.7 h, P = 0.009) as well as the application-delivery interval (29.8 +/- 22.0 h versus 62.0 +/- 78.8 h, P = 0.039). In the Propess group 62% delivered within 24 h compared to 28% in the Prepidil group. A smaller number of applications was observed in the Propess group (1.2 versus 1.8, P < 0.005). Both methods proved to be safe in cervical priming and no relevant differences in mode of delivery and outcome of labour were detected. None of the patients required an emergency caesarean section during the treatment with prostaglandines. CONCLUSIONS: Both prostaglandin E(2) agents are safe and effective in achieving cervical ripening; however the vaginal insert demonstrated a shorter application-delivery interval. The hospital stay was consequently shorter, contributing to cost effectiveness. |
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Authors:
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A Vollebregt; D B van't Hof; N Exalto |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 104 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-03 Completed Date: 2003-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 116-9 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ireland Ltd. |
Affiliation:
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Department of Obstetrics and Gynaecology, Spaarne Ziekenhuis Haarlem, Afdeling Verloskunde en Gynaecologie, Postbus 1644, 2003 Haarlem BR, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravaginal Adult Cervical Ripening / drug effects* Cervix Uteri / drug effects Cesarean Section Dinoprostone / administration & dosage*, therapeutic use* Female Gestational Age Heart Rate, Fetal Humans Hypertension Labor, Induced Male Pregnancy Pregnancy Complications, Cardiovascular Pregnancy Outcome Pregnancy, Prolonged / drug effects Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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363-24-6/Dinoprostone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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