Document Detail

Preparing individuals to communicate genetic test results to their relatives: report of a randomized control trial.
MedLine Citation:
PMID:  23420550     Owner:  NLM     Status:  MEDLINE    
This study reports a randomized clinical trial evaluating the efficacy of an intervention to prepare individuals to communicate BRCA1/BRCA2 results to family members. Women aged 18 years and older, who had genetic testing, and who had adult first-degree relatives, were randomly assigned to a communication skills-building intervention or a wellness control session. Primary outcomes were the percentage of probands sharing test results, and the level of distress associated with sharing. The ability of the theory of planned behavior variables to predict the outcomes was explored. Four hundred twenty-two women were enrolled in the study, 219 (intervention) and 203 (control). Data from 137 in the intervention group and 112 in the control group were analyzed. Two hundred forty-nine probands shared test results with 838 relatives (80.1 %). There were no significant differences between study groups in the primary outcomes. Combining data from both arms revealed that perceived control and specific social influence were associated with sharing. Probands were more likely to share genetic test results with their children, female relatives and relatives who they perceived had a favorable opinion about learning the results. The communication skills intervention did not impact sharing of test results. The proband's perception of her relative's opinion of genetic testing and her sense of control in relaying this information influenced sharing. Communication of test results is selective, with male relatives and parents less likely to be informed. Prevalent psychosocial factors play a role in the communication of genetic test results within families.
Susan V Montgomery; Andrea M Barsevick; Brian L Egleston; Ruth Bingler; Karen Ruth; Suzanne M Miller; John Malick; Terrence P Cescon; Mary B Daly
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Familial cancer     Volume:  12     ISSN:  1573-7292     ISO Abbreviation:  Fam. Cancer     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-08     Completed Date:  2014-05-22     Revised Date:  2014-11-16    
Medline Journal Info:
Nlm Unique ID:  100898211     Medline TA:  Fam Cancer     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  537-46     Citation Subset:  IM    
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MeSH Terms
BRCA1 Protein / genetics
BRCA2 Protein / genetics
Breast Neoplasms / diagnosis,  genetics,  psychology*
Case-Control Studies
Family / psychology*
Follow-Up Studies
Genetic Counseling
Genetic Predisposition to Disease
Genetic Testing*
Intervention Studies
Middle Aged
Mutation / genetics
Ovarian Neoplasms / diagnosis,  genetics,  psychology*
Grant Support
P30 CA00692/CA/NCI NIH HHS; P30 CA006927/CA/NCI NIH HHS; R01 CA081867/CA/NCI NIH HHS; R01 CA81867/CA/NCI NIH HHS
Reg. No./Substance:
0/BRCA1 Protein; 0/BRCA1 protein, human; 0/BRCA2 Protein; 0/BRCA2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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