Document Detail

Preparing the United States for high-sensitivity cardiac troponin assays.
MedLine Citation:
PMID:  23395074     Owner:  NLM     Status:  MEDLINE    
It is only a matter of time before the use of high-sensitivity cardiac troponin assays (hs-cTn) becomes common throughout the United States. In preparation for this inevitability, this article raises a number of important issues regarding these assays that deserve consideration. These include: the need for the adoption of a universal nomenclature; the importance of defining uniform criteria for reference populations; the challenge of discriminating between acute and nonacute causes of hs-cTn elevations, and between type 1 and type 2 acute myocardial infarction (AMI); factors influencing the analytical precision of hs-cTn; ascertaining the optimal duration of the rule-out period for AMI; the need for further evaluation to determine the causes of a positive hs-cTn in non-AMI patients; and the use of hs-cTn to risk-stratify patients with disease conditions other than AMI. This review elaborates on these critical issues as a means of educating clinicians and researchers about them.
Frederick K Korley; Allan S Jaffe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-02-06
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  61     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-06-17     Revised Date:  2013-09-27    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1753-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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MeSH Terms
Acute Disease
Biological Markers / blood
Chronic Disease
Diagnosis, Differential
Myocardial Infarction / blood*,  diagnosis*
Patient Selection
Sensitivity and Specificity
Terminology as Topic
Troponin / blood*
United States
Reg. No./Substance:
0/Biological Markers; 0/Troponin
Comment In:
J Am Coll Cardiol. 2013 Aug 13;62(7):647-8   [PMID:  23643503 ]
J Am Coll Cardiol. 2013 Aug 13;62(7):648   [PMID:  23643505 ]

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