Document Detail


Preparing Glabridin-in-Water Nanoemulsions by High Pressure Homogenization with Response Surface Methodology.
MedLine Citation:
PMID:  22975782     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Glabridin is a pharmacological active hydrophobic pyranoisoflavan isolated from licorice. It has low bioavailability and solubility and therefore is difficult to apply for industry use. We investigated the effect of combining caprylic triglyceride with glabridin (2-6%, w/w), emulsifier (3-7%, w/w), and homogenization pressure (70-130 MPa) on the droplet size of glabridin nanoemulsions using response surface methodology by a 3-factor-3-level Box-Behnken design. Oil content, emulsifier content and pressure had a significant effect on droplet size (p < 0.05). The optimal conditions for preparing glabridin nanoemulsions were predicted to be caprylic triglyceride (oil content), 3.7%; emulsifier content, 5.3%, and homogenization pressure, 129 MPa.
Authors:
Chang-Wei Hsieh; Po-Hsien Li; I-Chi Lu; Teng-Hsu Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oleo science     Volume:  61     ISSN:  1347-3352     ISO Abbreviation:  J Oleo Sci     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101175339     Medline TA:  J Oleo Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  IM    
Affiliation:
Department of Medicinal Botany and Healthcare, Da-Yeh University.
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