| Preparation and thermosensitivity of naturally occurring polypeptide poly(gamma-glutamic acid) derivatives modified by propyl groups. | |
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MedLine Citation:
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PMID: 15468231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(gamma-glutamic acid) (gamma-PGA) is a biosynthetic polymer, and the carboxyl groups are able to undergo a chemical modification. In this study, poly(alpha-propyl gamma-glutamate) (gamma-PGA propylate) was synthesized by the esterification of these carboxyl groups to yield a thermosensitive and biodegradable polymer. In aqueous solution, the gamma-PGA propylate can impart thermosensitivity by controlling the hydrophobic-hydrophilic balance of the gamma-PGA polymeric chains. |
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Authors:
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Taiki Shimokuri; Tatsuo Kaneko; Takeshi Serizawa; Mitsuru Akashi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Macromolecular bioscience Volume: 4 ISSN: 1616-5187 ISO Abbreviation: Macromol Biosci Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-10-06 Completed Date: 2005-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 407-11 Citation Subset: IM |
Affiliation:
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Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Stability Esters Magnetic Resonance Spectroscopy Polyglutamic Acid / chemical synthesis, chemistry* Propionic Acids Structure-Activity Relationship Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Esters; 0/Propionic Acids; 25513-46-6/Polyglutamic Acid; 79-09-4/propionic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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