Document Detail


Preparation of some prostaglandin E1 and omega-homo-prostaglandin E1 esters and their inhibiting properties on rat blood platelet aggregation.
MedLine Citation:
PMID:  704904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various esters of omega-homo-prostaglandin E1 and prostaglandin E1 were prepared in a yield of 28-55% to investigate their effect on ADP-induced aggregation of rat blood platelets. The biopotency of the omega-homo-PGE1-esters is about four times higher than that of the corresponding PGE1-esters. Furthermore, the biopotency of aliphatic esters decreases with increasing chain length of the ester group.
Authors:
L van der Wolf; J Kloeze; H J Pabon; D A van Dorp
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  15     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  795-801     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Methods
Platelet Aggregation / drug effects*
Prostaglandins E, Synthetic / chemical synthesis*,  pharmacology
Rats
Chemical
Reg. No./Substance:
0/Prostaglandins E, Synthetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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