Document Detail


Preparation of raf-oncogene-specific antiserum with raf protein produced in E. coli.
MedLine Citation:
PMID:  3277669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this report we describe the expression of v-raf protein in E. coli using a tryptophan-promoter-driven expression vector and its immunological characterization by anti-peptide sera. The purified recombinant protein was used to produce raf-specific antibodies which are suitable for studying v-raf and c-raf proteins in vitro and in vivo in a variety of species ranging from mouse to man.
Authors:
W Kolch; A M Schultz; H Oppermann; U R Rapp
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  949     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-04-01     Completed Date:  1988-04-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  233-9     Citation Subset:  IM    
Affiliation:
Laboratory of Viral Carcinogenesis, NCI-Frederick Cancer Research Facility, MD 21701.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Antibody Specificity
Chemical Precipitation
Cloning, Molecular
Escherichia coli / genetics
Molecular Weight
Oncogenes*
Peptide Fragments / immunology
Recombinant Proteins / immunology*
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
N01-C0-74101//PHS HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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