Document Detail

Preparation and preliminary cytocompatibility of magnesium doped apatite cement with degradability for bone regeneration.
MedLine Citation:
PMID:  21258847     Owner:  NLM     Status:  Publisher    
In the present study, we fabricated magnesium doped apatite cement (md-AC) with rapid self-setting characteristic by adding the mixed powders of magnesium oxide and calcium dihydrogen phosphate (MO-CDP) into hydroxyapatite cement (HAC). The results revealed that the md-AC with 50 wt% MO-CDP could set within 6 min and the compression strength could reach 51 MPa after setting for 1 h, indicating that the md-AC had highly initial mechanical strength. The degradability of the md-AC in Tris-HCl solution increased with the increase of MO-CDP amount, and the weight loss ratio of md-AC with 50 wt% MO-CDP was 57.5 wt% after soaked for 12 weeks. Newly flake-like apatite could be deposited on the md-AC surfaces after soaked in simulated body fluid (SBF) for 7 days. Cell proliferation ratio of MG(63) cells on md-AC was obviously higher than that of HAC on days 4 and 7. The cells with normal phenotype spread well on the md-AC surfaces and attached intimately with the substrate, and alkaline phosphatase (ALP) activity of the cells on md-AC significantly improved compared with HAC on day 7. The results demonstrate that the md-AC has a good ability to support cell proliferation and differentiation, and indicate a good cytocompatibility.
Jingxiong Lu; Jie Wei; Yonggang Yan; Hong Li; Junfeng Jia; Shicheng Wei; Han Guo; Tiqiao Xiao; Changsheng Liu
Related Documents :
3622637 - Sterol depletion reduces receptor-mediated low-density lipoprotein binding in ns-1 mous...
19555197 - Effect of hmg-coa reductase inhibitors on activation of human gammadeltat cells induced...
11931707 - Expression of intercellular adhesion molecule-1 in u937 foam cells and inhibitory effec...
1794867 - Effect of supplementation of ergosterol on miconazole action in vivo and in vitro in ca...
9566957 - Role of differential cell proliferation in the tail bud in aberrant mouse neurulation.
15667977 - Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-22
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  -     ISSN:  1573-4838     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of blasting treatment and Fn coating on MG63 adhesion and differentiation on titanium: a gene...
Next Document:  Effectiveness of an interactive website aimed at empowerment of disability benefit claimants: result...