| Preparation of polymeric and ceramic porous capsules by a novel electrohydrodynamic process. | |
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MedLine Citation:
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PMID: 18720243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preparation of capsules for medical and industrial use can be achieved via several conventional routes, yielding either hard or soft receptacles, depending on the type and the content of the material to be encapsulated. Together with tablets, capsules are amongst the most commonly used means of administering medication and this makes progress in capsule preparation technology a key area of drug delivery research. Here we uncover new technology for the preparation of capsules with porous chambers. The novelty is signified in the use of an electrohydrodynamic process engineering route and its potential is elucidated using a polymeric material; polymethylsilsesquioxane, which can be converted into an identical ceramic form by means of simple pyrolysis. Thus, both polymeric and ceramic capsules have been prepared. The effects of process control parameters such as the applied voltage and flow rate, on the characteristics of the capsules prepared are discussed. |
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Authors:
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M Nangrejo; Z Ahmad; E Stride; M Edirisinghe; P Colombo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmaceutical development and technology Volume: 13 ISSN: 1097-9867 ISO Abbreviation: Pharm Dev Technol Publication Date: 2008 |
Date Detail:
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Created Date: 2008-09-17 Completed Date: 2008-11-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9610932 Medline TA: Pharm Dev Technol Country: United States |
Other Details:
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Languages: eng Pagination: 425-32 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, University College London, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Capsules Ceramics / chemistry Drug Carriers / chemistry* Electronics Hot Temperature Organosilicon Compounds / chemistry* Polymers / chemistry* Porosity Technology, Pharmaceutical / methods* |
| Chemical | |
Reg. No./Substance:
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0/Capsules; 0/Ceramics; 0/Drug Carriers; 0/Organosilicon Compounds; 0/Polymers; 0/polymethylsilsesquioxane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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