Document Detail


Preparation and pharmacological evaluation of physostigmine-loaded polyisobutylcyanoacrylate nanoparticles in rats.
MedLine Citation:
PMID:  9519684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nanoparticles of physostigmine were prepared by an emulsion polymerization of polyisobutylcyanoacrylate. The drug content, release and particle size distribution of the nanoparticles were characterized. In vitro drug release profiles displayed a retardation by the nanoparticles in comparison to the aqueous solution. Pharmacological evaluation of physostigmine nanoparticles in vivo were carried out with Sprague-Dawley rats. The endogenous acetylcholine was sampled by on-line microdialysis and determined by a sensitive microbore HPLC/ED system in the striatum of rats. The choline oxidase and catalase immobilized enzyme reactors were used as the pre-column to erase choline. Accordingly, this chromatographic flow sequence could be utilized for the quantitative assay of acetylcholine without interference. The results indicate that the increase of acetylcholine (%) in the rats striatum by the nanoparticle was 2.3 times (AUC) higher than that of aqueous solution.
Authors:
T R Tsai; W H Chuo; C W Lin; T M Cham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Kaohsiung journal of medical sciences     Volume:  14     ISSN:  1607-551X     ISO Abbreviation:  Kaohsiung J. Med. Sci.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100960562     Medline TA:  Kaohsiung J Med Sci     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Affiliation:
School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / secretion
Animals
Cholinesterase Inhibitors / administration & dosage*
Cyanoacrylates / administration & dosage*
Drug Carriers
Male
Microdialysis
Physostigmine / administration & dosage*
Polymers / administration & dosage*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Cholinesterase Inhibitors; 0/Cyanoacrylates; 0/Drug Carriers; 0/Polymers; 26809-38-1/polyisobutyl cyanoacrylate; 51-84-3/Acetylcholine; 57-47-6/Physostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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