| Preparation of new omega-aldehydoalkyl 1-thio-D-glycopyranosides, and their coupling to bovine serum albumin by reductive alkylation. | |
| | |
MedLine Citation:
|
PMID: 7060055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Synthesis of two omega-aldehydoalkyl 1-thioglycosides of D-glucopyranose and of D-galactopyranose is described. 3-Oxopropyl and 2-oxoethyl 1-thioglycosides were prepared by treating a tetra-O-acetyl-1-thioaldose with either acrolein or 2-bromo-acetaldehyde, followed by O-deacetylation under mild conditions. These omega-aldehydoalkyl 1-thioglycosides were successfully attached to bovine serum albumin (BSA) by reductive alkylation as described previously. With the 3-oxopropyl 1-thioglycosides, much higher levels of sugar attachment (e.g., approximately 80 mol of sugar per mol of BSA) were attained than hitherto possible with any sugar derivative tested. |
| | |
Authors:
|
R T Lee; Y C Lee |
Related Documents
:
|
1246375 - Progestational potency of oral contraceptives. 3720795 - Urinary excretion of conjugates of dothiepin and northiaden (mono-n-demethyl-dothiepin)... 16469415 - Investigation on recombinant hirudin via oral route. 2875395 - L-654,284 a new potent and selective alpha 2-adrenoceptor antagonist. 1246375 - Progestational potency of oral contraceptives. 16964295 - Erucism in new zealand: exposure to gum leaf skeletoniser (uraba lugens) caterpillars i... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Carbohydrate research Volume: 101 ISSN: 0008-6215 ISO Abbreviation: Carbohydr. Res. Publication Date: 1982 Feb |
Date Detail:
|
Created Date: 1982-05-21 Completed Date: 1982-05-21 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0043535 Medline TA: Carbohydr Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 49-55 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkylation Animals Cattle Indicators and Reagents Kinetics Magnetic Resonance Spectroscopy Protein Binding Serum Albumin, Bovine* Thioglycosides / chemical synthesis* |
| Grant Support | |
ID/Acronym/Agency:
|
AM9970/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Indicators and Reagents; 0/Serum Albumin, Bovine; 0/Thioglycosides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preparation of some (1 goes to 6)-linked disaccharides, and their derivatives suitable for protein m...
Next Document: Isolation and partial characterization of an extracellular glucansucrase from Leuconostoc mesenteroi...